This article was presented at the 51th annual meeting of the American Academy of Child and Adolescent Psychiatry, Washington DC, October 19–24, 2004.
Abnormal thalamic volume in treatment-naïve boys with Tourette syndrome
Article first published online: 14 NOV 2005
Acta Psychiatrica Scandinavica
Volume 113, Issue 1, pages 64–67, January 2006
How to Cite
Lee, J.-S., Yoo, S.-S., Cho, S.-Y., Ock, S.-M., Lim, M.-K. and Panych, L. P. (2006), Abnormal thalamic volume in treatment-naïve boys with Tourette syndrome. Acta Psychiatrica Scandinavica, 113: 64–67. doi: 10.1111/j.1600-0447.2005.00666.x
- Issue published online: 14 NOV 2005
- Article first published online: 14 NOV 2005
- Accepted for publication September 19, 2005
- Tourette syndrome;
- magnetic resonance imaging
Objective: Thalamic abnormality has been implicated in the pathophysiology of Tourette's syndrome (TS). We examined the presence of aberrant thalamic volume from the treatment-naïve boys with TS using magnetic resonance imaging (MRI).
Method: Volumetric MRI was performed on 18 treatment-naïve boys with TS, aged 7–14 years, and 16 healthy comparison subjects. The anatomical boundaries were then manually parcellated to measure the thalamic volume.
Results: Tourette's syndrome subjects had a significantly larger left thalamus in comparison with those of healthy subjects. On the contrary, no group difference was observed from the right thalamic volume. TS subjects also showed a significant reduction in rightward asymmetry in thalamic volume compared with the healthy subjects.
Conclusion: Our findings provide new evidence of abnormal thalamic volume in pediatric TS.