Abnormal thalamic volume in treatment-naïve boys with Tourette syndrome

  1. J.-S. Lee1,
  2. S.-S. Yoo2,
  3. S.-Y. Cho1,
  4. S.-M. Ock3,
  5. M.-K. Lim4,
  6. L. P. Panych2

Article first published online: 14 NOV 2005

DOI: 10.1111/j.1600-0447.2005.00666.x

Issue

Acta Psychiatrica Scandinavica

Acta Psychiatrica Scandinavica

Volume 113, Issue 1, pages 64–67, January 2006

Additional Information

How to Cite

Lee, J.-S., Yoo, S.-S., Cho, S.-Y., Ock, S.-M., Lim, M.-K. and Panych, L. P. (2006), Abnormal thalamic volume in treatment-naïve boys with Tourette syndrome. Acta Psychiatrica Scandinavica, 113: 64–67. doi: 10.1111/j.1600-0447.2005.00666.x

Author Information

  1. 1

    Department of Psychiatry, Inha University Hospital and College of Medicine, Incheon, South Korea

  2. 2

    Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

  3. 3

    Department of Family Medicine, Catholic University Medical College, Uijongbu

  4. 4

    Department of Radiology, Inha University Hospital and College of Medicine, Incheon, South Korea

*Jeong-Seop Lee, Department of Psychiatry, Inha University Hospital and College of Medicine, 7-206, 3-Ga, Shinheung-Dong, Jung-Gu, Incheon 400–711, South Korea. E-mail: soulfree@inha.ac.kr

Publication History

  1. Issue published online: 14 NOV 2005
  2. Article first published online: 14 NOV 2005
  3. Accepted for publication September 19, 2005

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Keywords:

  • Tourette syndrome;
  • thalamus;
  • magnetic resonance imaging

Objective:  Thalamic abnormality has been implicated in the pathophysiology of Tourette's syndrome (TS). We examined the presence of aberrant thalamic volume from the treatment-naïve boys with TS using magnetic resonance imaging (MRI).

Method:  Volumetric MRI was performed on 18 treatment-naïve boys with TS, aged 7–14 years, and 16 healthy comparison subjects. The anatomical boundaries were then manually parcellated to measure the thalamic volume.

Results:  Tourette's syndrome subjects had a significantly larger left thalamus in comparison with those of healthy subjects. On the contrary, no group difference was observed from the right thalamic volume. TS subjects also showed a significant reduction in rightward asymmetry in thalamic volume compared with the healthy subjects.

Conclusion:  Our findings provide new evidence of abnormal thalamic volume in pediatric TS.

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