This paper is part of the TIPS project with the following research group: T. McGlashan MD (PI), P. Vaglum MD (PI), S. Friis MD, U. Haahr MD, J.O. Johannessen MD, T.K. Larsen MD, I. Melle MD, S. Opjordsmoen MD, B.R. Rund PhD, E. Simonsen MD. From the Department of Psychiatry, Yale University, New Haven, CT, USA; Mid sector, Roskilde Psychiatric University Hospital Fjorden, Denmark; Stavanger University Hospital; Haugesund Hospital; Ullevål University Hospital and the Departments of Psychiatry, Psychology and Behavioral Sciences in Medicine, University of Oslo, Norway. (PI, Principal Investigator)
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Clinical epidemiologic first-episode psychosis: 1-year outcome and predictors
Article first published online: 23 JAN 2007
DOI: 10.1111/j.1600-0447.2006.00942.x
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How to Cite
Simonsen, E., Friis, S., Haahr, U., Johannessen, J. O., Larsen, T. K., Melle, I., Opjordsmoen, S., Rund, B. R., Vaglum, P. and McGlashan, T. (2007), Clinical epidemiologic first-episode psychosis: 1-year outcome and predictors. Acta Psychiatrica Scandinavica, 116: 54–61. doi: 10.1111/j.1600-0447.2006.00942.x
Publication History
- Issue published online: 9 MAY 2007
- Article first published online: 23 JAN 2007
- Accepted for publication October 20, 2006
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Keywords:
- schizophrenia;
- first episode;
- outcome;
- predictors
Objective: To describe 1-year outcome in a large clinical epidemiologic sample of first-episode psychosis and its predictors.
Method: A total of 301 patients with first-episode psychosis from four healthcare sectors in Norway and Denmark receiving common assessments and standardized treatment were evaluated at baseline, at 3 months, and at 1 year.
Results: Substantial clinical and social improvements occurred within the first 3 months. At 1-year 66% were in remission, 11% in relapse, and 23% continuously psychotic. Female gender and better premorbid functioning were predictive of less severe negative symptoms. Shorter DUP was predictive for shorter time to remission, stable remission, less severe positive symptoms, and better social functioning. Female gender, better premorbid social functioning and more education also contributed to a better social functioning.
Conclusion: This first-episode sample, being well treated, may be typical of the early course of schizophrenia in contemporary centers.