Presented at the Conference: ‘Melancholia: Beyond DSM, Beyond Neurotransmitters’, May 2–4, 2006, Copenhagen, Denmark.
The facets of melancholia
Article first published online: 15 JAN 2007
Acta Psychiatrica Scandinavica
Volume 115, Issue Supplement s433, pages 31–36, February 2007
How to Cite
Coryell, W. (2007), The facets of melancholia. Acta Psychiatrica Scandinavica, 115: 31–36. doi: 10.1111/j.1600-0447.2007.00960.x
- Issue published online: 15 JAN 2007
- Article first published online: 15 JAN 2007
- diagnostic criteria
Objective: To clarify the role of ‘melancholia’ in psychiatric nomenclature.
Most clinicians and researchers are convinced that the syndrome currently termed major depressive disorder encompasses multiple subgroups that differ meaningfully in phenomenology, natural history, treatment response, and pathophysiology. Delusional depression and melancholia have attracted the most empirical work, but efforts to define the latter condition have declined in recent years following a number of failures to show the validity of the melancholic/nonmelancholic distinction.
Method: Review of experience.
Results: Beyond the DSM-IV symptom profile, melancholia has been associated with greater overall severity, a low likelihood of placebo response, an episodic course, a family history of depression without alcoholism, a relatively healthy personality, and hypothalamic-pituitary-adrenal axis hyperactivity. Evidence for the validity of the melancholia concept lies in the fact that the presence of each of these characteristics has been shown to increase the likelihood of one or more of the others.
Conclusion: A diagnosis of melancholia may eventually prove valuable in treatment selection, but the necessary evidence will not be forthcoming until a widely accepted definition exists that is both inherently valid and that can be applied consistently across research sites.