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Keywords:

  • depression;
  • antidepressive agents;
  • meta-analysis;
  • transcranial magnetic stimulation;
  • electric stimulation therapy

Objective:  To investigate whether the recent repetitive transcranial magnetic stimulation (rTMS) studies on depression using new parameters of stimulation have shown improved clinical results.

Method:  We performed a systematic review and a meta-analysis of the rTMS studies on depression published in the past 12 months comparing these results with an earlier meta-analysis that analyzed the results of the initial rTMS studies on depression.

Results:  Using our inclusion criteria, we selected the meta-analysis of Martin [Br J Psychiatry (2003) Vol. 182, 480–491] that included 13 studies (324 patients) and five studies for the recent meta-analysis (274 patients). The pooled effect size (standardized mean difference between pretreatment vs. post-treatment) from the random effects model was −0.76 (95% confidence interval, CI, −1.01 to −0.51). This result was significantly larger than that of the earlier meta-analysis (−0.35, 95% CI −0.66 to −0.04).

Conclusion:  Our findings suggest that recent rTMS clinical trials have shown larger antidepressant effects when compared with the earlier studies.