Clinical and neurocognitive correlates of insight in patients with bipolar I disorder in remission
Version of Record online: 28 OCT 2007
Acta Psychiatrica Scandinavica
Volume 117, Issue 1, pages 28–34, January 2008
How to Cite
Dias, V. V., Brissos, S. and Carita, A. I. (2008), Clinical and neurocognitive correlates of insight in patients with bipolar I disorder in remission. Acta Psychiatrica Scandinavica, 117: 28–34. doi: 10.1111/j.1600-0447.2007.01110.x
- Issue online: 28 OCT 2007
- Version of Record online: 28 OCT 2007
- Accepted for publication September 21, 2007
- frontal lobe;
Objective: The relationship between insight and neurocognition in bipolar disorder has not been clearly established.
Method: A neuropsychological battery assessing attention, mental control, perceptual-motor skills, executive functions, verbal fluency and abstraction, and visuo-spatial attention was administered to 50 bipolar remitted patients and 50 healthy controls. Insight was assessed with the Scale to Assess Unawareness of Mental Disorder.
Results: Patients presented significantly worse neurocognitive performance. Insight was impaired in 60% of patients, and age, educational level, manic symptoms, age of disease onset, number of admissions, and performance on several neurocognitive tests correlated significantly with insight. A regression model revealed that age and Trail Making Test part B (TMT-B) performance accounted for 32% of the variance in overall illness awareness, while performance on the TMT-B alone accounted for 28% of the variance.
Conclusion: Impaired insight and neurocognitive dysfunction seem to be present in euthymic bipolar patients. Insight in bipolar disorder may be partially dependent on intact neurocognition.