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Insulin resistance and lipid levels in adolescents with familial risk for psychosis


Hannu Koponen, Department of Psychiatry, University of Kuopio, and Academy of Finland, PO Box 1777, FIN-70211 Kuopio, Finland.


Objective:  Type 2 diabetes and dyslipidemias co-occur frequently with schizophrenia. It is not known how common they are in adolescents with a familial risk for psychosis.

Method:  The Northern Finland 1986 Birth Cohort consists of 9432 children born alive in the two Northernmost provinces in Finland. At the age of 15/16 they participated in clinical examination including measurements of glucose, lipids and IR, and a questionnaire including items about their diet and physical activity. The Finnish Hospital Discharge Register was used to find out non-organic psychoses in parents during 1972–2000. This familial risk was found out in 54 boys and 68 girls. Their results were compared with other cohort members.

Results:  No differences were observed in the cardiometabolic risk factors between the study groups.

Conclusion:  Our results suggest that familial risk for psychosis is not directly associated with disturbances of glucose and lipid metabolism among adolescents.