Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder
Article first published online: 26 FEB 2008
© 2008 The Authors
Acta Psychiatrica Scandinavica
Volume 117, Issue 4, pages 271–276, April 2008
How to Cite
Iosifescu, D. V., Greenwald, S., Devlin, P., Perlis, R. H., Denninger, J. W., Alpert, J. E. and Fava, M. (2008), Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder. Acta Psychiatrica Scandinavica, 117: 271–276. doi: 10.1111/j.1600-0447.2008.01156.x
- Issue published online: 26 FEB 2008
- Article first published online: 26 FEB 2008
- Accepted for publication December 19, 2007
- major depressive disorder;
- quantitative electroencephalography;
- suicidal ideation;
- selective serotonin reuptake inhibitors
Objective: We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD).
Method: Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment.
Results: During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized.
Conclusion: Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.