Neuroimaging genetics: new perspectives in research on major depression?
Article first published online: 17 JUL 2008
Copyright © 2008 The Authors. Journal Compilation © 2008 Blackwell Munksgaard
Acta Psychiatrica Scandinavica
Volume 118, Issue 5, pages 363–372, November 2008
How to Cite
Frodl, T., Möller, H.-J. and Meisenzahl, E. (2008), Neuroimaging genetics: new perspectives in research on major depression?. Acta Psychiatrica Scandinavica, 118: 363–372. doi: 10.1111/j.1600-0447.2008.01225.x
- Issue published online: 9 OCT 2008
- Article first published online: 17 JUL 2008
- Accepted for publication May 19, 2008
- major depression;
- neuroimaging genetics;
Objective: Stress-related changes in the hippocampus are influenced by genetic factors. To enhance our understanding of both the interaction between the brain, behaviour and genetics and of biological mechanisms in mood disorders neuroimaging genetics provide a good opportunity.
Method: A MEDLINE search was conducted to identify articles on neuroimaging genetics in major depression (MD).
Results: Hippocampal volumes were found to be associated with polymorphisms in the promotor region of the serotonin transporter (5-HTTLPR) in patients with MD. Met-allele carriers of the BDNF (val66met) polymorphism had smaller hippocampal volumes in both patients and healthy controls when compared with homozygous val-allele carriers. Polymorphisms of the serotonin transporter (5-HTTLPR) and 5-HT1a receptor are associated with increased amygdala activation investigated with functional MRI in patients with MD.
Conclusion: Genetic variants seem to modulate the effects of stress on hippocampal volumes as well as amygdala activity as well as the development of the brain.