Misclassification and the use of register-based indicators for depression
Article first published online: 11 DEC 2008
Copyright © 2008 The Authors. Journal Compilation © 2008 Blackwell Munksgaard
Acta Psychiatrica Scandinavica
Volume 119, Issue 4, pages 312–319, April 2009
How to Cite
Thielen, K., Nygaard, E., Andersen, I., Rugulies, R., Heinesen, E., Bech, P., Bültmann, U. and Diderichsen, F. (2009), Misclassification and the use of register-based indicators for depression. Acta Psychiatrica Scandinavica, 119: 312–319. doi: 10.1111/j.1600-0447.2008.01282.x
- Issue published online: 3 MAR 2009
- Article first published online: 11 DEC 2008
- Accepted for publication September 19, 2008
- outcome measurement error;
- antidepressive agents;
- population registries
Objective: To study the degree to which depression indicators based on register data on hospital and antidepressant treatment suffer from differential misclassification with respect to gender, age and social group.
Method: Data on 7378 persons were obtained by linking a cross-sectional survey of Danish adults aged 40 and 50 years with population-based registers. Misclassification was analysed by comparing survey data to register data on major depression using the method proposed by Rothman and Greenland.
Results: Differential misclassification was found. Adjustment for misclassification reduced women’s odds ratios from 2.18 to 1.00 for hospital treatment and from 1.70 to 1.10 for antidepressants. For the lower social group, the corresponding odds ratios increased from 1.18 to 3.52, and from 1.35 to 2.32 respectively, whereas odds ratios with respect to age remained almost unchanged.
Conclusion: Differential misclassification should be considered when register-based information about hospital and antidepressant treatment are used as depression indicators.