Impact of substance use on the physical health of patients with bipolar disorder

  1. M. P. Garcia-Portilla1,2,
  2. P. A. Saiz1,2,
  3. A. Benabarre2,3,
  4. G. Florez4,
  5. M. T. Bascaran1,2,
  6. E. M. Díaz1,2,
  7. M. Bousoño1,2,
  8. J. Bobes1,2

Article first published online: 5 NOV 2009

DOI: 10.1111/j.1600-0447.2009.01498.x

Issue

Acta Psychiatrica Scandinavica

Acta Psychiatrica Scandinavica

Volume 121, Issue 6, pages 437–445, June 2010

Additional Information

How to Cite

Garcia-Portilla, M. P., Saiz, P. A., Benabarre, A., Florez, G., Bascaran, M. T., Díaz, E. M., Bousoño, M. and Bobes, J. (2010), Impact of substance use on the physical health of patients with bipolar disorder. Acta Psychiatrica Scandinavica, 121: 437–445. doi: 10.1111/j.1600-0447.2009.01498.x

Author Information

  1. 1

    Department of Psychiatry, University of Oviedo, Oviedo

  2. 2

    Instituto de Salud Carlos III, Centro de Investigación en Red de Salud Mental, CIBERSAM

  3. 3

    Hospital Clinic, Barcelona

  4. 4

    Adictive Behaviour Unit, SERGAS, Ourense, Spain

*María P. García-Portilla, Department of Psychiatry, School of Medicine, University of Oviedo, Julián Clavería 6, 33006 Oviedo, Spain. E-mail: albert@uniovi.es

Publication History

  1. Issue published online: 4 MAY 2010
  2. Article first published online: 5 NOV 2009
  3. Accepted for publication September 30, 2009

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Keywords:

  • bipolar disorder;
  • substance use;
  • metabolic syndrome;
  • coronary heart disease;
  • cardiovascular mortality risk

Garcia-Portilla MP, Saiz PA, Benabarre A, Florez G, Bascaran MT, Díaz EM, Bousoño M, Bobes J. Impact of substance use on the physical health of patients with bipolar disorder.

Objective:  To describe the impact of tobacco, alcohol and cannabis on metabolic profile and cardiovascular risk in bipolar patients.

Method:  Naturalistic, cross-sectional, multicenter Spanish study. Current use of tobacco, alcohol and cannabis was determined based on patient self-reports. Metabolic syndrome was defined using the National Health and Nutrition Examination Survey 1999–2000 and the American Heart Association/National Heart, Lung and Blood Institute criteria, and cardiovascular risk using the Framingham and the Systematic Coronary Risk Evaluation functions.

Results:  Mean age was 46.6 years, 49% were male. Substance use: 51% tobacco, 13% alcohol and 12.5% cannabis. Patients who reported consuming any substance were significantly younger and a higher proportion was male. After controlling for confounding factors, tobacco was a risk factor for coronary heart disease (CHD) (unstandardized linear regression coefficient 3.47, 95% confidence interval 1.85–5.10).

Conclusion:  Substance use, mainly tobacco, was common in bipolar patients. Tobacco use negatively impacted CHD risk.

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