Trial registration: http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1144.
A randomized controlled study of paroxetine and cognitive-behavioural therapy for late-life panic disorder
Article first published online: 3 DEC 2009
© 2009 John Wiley & Sons A/S
Acta Psychiatrica Scandinavica
Volume 122, Issue 1, pages 11–19, July 2010
How to Cite
Hendriks, G.-J., Keijsers, G. P. J., Kampman, M., Oude Voshaar, R. C., Verbraak, M. J. P. M., Broekman, T. G. and Hoogduin, C. A. L. (2010), A randomized controlled study of paroxetine and cognitive-behavioural therapy for late-life panic disorder. Acta Psychiatrica Scandinavica, 122: 11–19. doi: 10.1111/j.1600-0447.2009.01517.x
- Issue published online: 1 JUN 2010
- Article first published online: 3 DEC 2009
- Accepted for publication November 6, 2009
- panic disorders;
- randomized controlled trial
Hendriks G-J, Keijsers GPJ, Kampman M, Oude Voshaar RC, Verbraak MJPM, Broekman TG, Hoogduin CAL. A randomized controlled study of paroxetine and cognitive-behavioural therapy for late-life panic disorder.
Objective: To examine the effectiveness of paroxetine and cognitive-behavioural therapy (CBT) in elderly patients suffering from panic disorder with or without agoraphobia (PD(A)).
Method: Forty-nine patients aged 60+ years with confirmed PD(A) were randomly assigned to 40 mg paroxetine, individual CBT, or to a 14-week waiting list. Outcomes, with avoidance behaviour and agoraphobic cognitions being the primary measures, were assessed at baseline and at weeks 8, 14 (conclusion CBT/waiting list), and at week 26 (treated patients only) and analysed using mixed models.
Results: All outcome measures showed that the patients having received CBT and those treated with paroxetine had significantly better improvement compared with those in the waiting-list condition. With one patient (1/20, 5%) in the CBT and three (3/14, 17.6%) in the paroxetine condition dropping out, attrition rates were low.
Conclusion: Patients with late-life panic disorder respond well to both paroxetine and CBT. Although promising, the outcomes warrant replication in larger study groups.