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Neural correlates of movement generation in the ‘at-risk mental state’

Authors

  • M. R. Broome,

    1. Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King’s College London, London
    2. Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
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  • P. Matthiasson,

    1. Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King’s College London, London
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  • P. Fusar-Poli,

    1. Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King’s College London, London
    2. Department of Applied and Psychobehavioural Health Sciences, University of Pavia, Pavia, Italy
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  • J. B. Woolley,

    1. Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King’s College London, London
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  • L. C. Johns,

    1. Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King’s College London, London
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  • P. Tabraham,

    1. Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King’s College London, London
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  • E. Bramon,

    1. Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King’s College London, London
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  • L. Valmaggia,

    1. Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King’s College London, London
    2. Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
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  • S. C. R. Williams,

    1. Neuroimaging Research Group, Department of Neurology, Institute of Psychiatry, King’s College London
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  • M. J. Brammer,

    1. Brain Image Analysis Unit, Department of Biostatistics and Computing, Institute of Psychiatry, King’s College London, London, UK
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  • X. Chitnis,

    1. Brain Image Analysis Unit, Department of Biostatistics and Computing, Institute of Psychiatry, King’s College London, London, UK
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  • P. K. McGuire

    1. Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King’s College London, London
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Matthew R. Broome, Warwick Medical School, University of Warwick, Gibbet Hill, Coventry CV4 7AL, UK.
E-mail: m.r.broome@warwick.ac.uk

Abstract

Broome MR, Matthiasson P, Fusar-Poli P, Woolley JB, Johns LC, Tabraham P, Bramon E, Valmaggia L, Williams SCR, Brammer MJ, Chitnis X, McGuire PK. Neural correlates of movement generation in the ‘at-risk mental state’.

Objective:  People with ‘prodromal’ symptoms have a very high risk of developing psychosis. We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task.

Method:  Cross-sectional comparison of individuals with an ARMS (n = 17), patients with first episode schizophreniform psychosis (n = 10) and healthy volunteers (n = 15). Subjects were studied using functional MRI while they performed a random movement generation paradigm.

Results:  During random movement generation, the ARMS group showed less activation in the left inferior parietal cortex than controls, but greater activation than in the first episode group.

Conclusion:  The ARMS is associated with abnormalities of regional brain function that are qualitatively similar to those in patients who have recently presented with psychosis but less severe.

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