Antidepressant medication prevents suicide in depression
Article first published online: 5 NOV 2010
© 2010 John Wiley & Sons A/S
Acta Psychiatrica Scandinavica
Volume 122, Issue 6, pages 454–460, December 2010
How to Cite
Isacsson, G., Reutfors, J., Papadopoulos, F. C., Ösby, U. and Ahlner, J. (2010), Antidepressant medication prevents suicide in depression. Acta Psychiatrica Scandinavica, 122: 454–460. doi: 10.1111/j.1600-0447.2010.01561.x
- Issue published online: 5 NOV 2010
- Article first published online: 5 NOV 2010
- Accepted for publication March 4, 2010
Vol. 125, Issue 5, 419, Article first published online: 10 MAR 2012
Isacsson G, Reutfors J, Papadopoulos FC, Ösby U, Ahlner J. Antidepressant medication prevents suicide in depression.
Objective: Ecological studies have demonstrated a substantial decrease in suicide in parallel with an increasing use of antidepressants. To investigate on the individual level the hypothesis that antidepressant medication was a causal factor.
Method: Data on the toxicological detection of antidepressants in 18 922 suicides in Sweden 1992–2003 were linked to registers of psychiatric hospitalization as well as registers with sociodemographic data.
Results: The probability for the toxicological detection of an antidepressant was lowest in the non-suicide controls, higher in suicides, and even higher in suicides that had been psychiatric in-patients but excluding those who had been in-patients for the treatment of depression.
Conclusion: The finding that in-patient care for depression did not increase the probability of the detection of antidepressants in suicides is difficult to explain other than by the assumption that a substantial number of depressed individuals were saved from suicide by postdischarge treatment with antidepressant medication.