Dose–response relationship of sertindole and haloperidol using the pharmacopsychometric triangle
Article first published online: 14 JUN 2010
© 2010 John Wiley & Sons A/S
Acta Psychiatrica Scandinavica
Volume 123, Issue 2, pages 154–161, February 2011
How to Cite
Bech, P., Tanghøj, P., Andreasson, K. and Overø, K. F. (2011), Dose–response relationship of sertindole and haloperidol using the pharmacopsychometric triangle. Acta Psychiatrica Scandinavica, 123: 154–161. doi: 10.1111/j.1600-0447.2010.01581.x
- Issue published online: 4 JAN 2011
- Article first published online: 14 JUN 2010
- Accepted for publication May 18, 2010
- rating scales;
- pharmacopsychometric triangle
Bech P, Tanghøj P, Andreasson K, Overø KF. Dose–response relationship of sertindole and haloperidol using the pharmacopsychometric triangle.
Objective: Renewed insight into dose-related effects of sertindole and haloperidol was sought by re-analysing published data for antipsychotic effect, extrapyramidal effect, and patient wellbeing – i.e., the important pharmacopsychometric triangle domains.
Method: Selected Positive and Negative Syndrome Scale (PANSS) subscales and the Simpson–Angus scale were tested for validity. Standardized effect sizes [last observation carried forward (LOCF)] at endpoint were calculated.
Results: The scales were found to be valid instruments. The PANSS11 psychotic subscale showed clinically significant effect sizes for all doses of sertindole (12, 20, and 24 mg) and haloperidol (4, 8, and 16 mg). Extrapyramidal effects were evident for all doses of haloperidol, but absent for the lower doses of sertindole. The PANSS6 depression subscale, a proxy measure of quality of life, showed a clinically significant effect for sertindole 20 mg and no effect for haloperidol.
Conclusion: This re-analysis confirmed the antipsychotic effect and absence of extrapyramidal effects for sertindole and, in addition, showed a clinically significant antidepressant effect. A profile for bipolar states emerged.