Manic episodes are associated with grey matter volume reduction — a voxel-based morphometry brain analysis
Article first published online: 15 AUG 2010
© 2010 John Wiley & Sons A/S
Acta Psychiatrica Scandinavica
Volume 122, Issue 6, pages 507–515, December 2010
How to Cite
Ekman, C. J., Lind, J., Rydén, E., Ingvar, M. and Landén, M. (2010), Manic episodes are associated with grey matter volume reduction — a voxel-based morphometry brain analysis. Acta Psychiatrica Scandinavica, 122: 507–515. doi: 10.1111/j.1600-0447.2010.01586.x
- Issue published online: 5 NOV 2010
- Article first published online: 15 AUG 2010
- Accepted for publication June 15, 2010
- bipolar disorder;
- magnetic resonance imaging;
- prefrontal cortex;
- disease progression
Ekman CJ, Lind J, Rydén E, Ingvar M, Landén M. Manic episodes are associated with grey matter volume reduction — a voxel-based morphometry brain analysis.
Objective: To investigate whether the lifetime number of affective episodes or illness duration is associated with changes in local grey matter volume, in patients with bipolar I disorder without comorbid conditions.
Method: Magnetic resonance imaging scans of 55 patients with bipolar I disorder were analysed using VBM.
Results: Smaller grey matter volume in the inferior frontal gyri of the dorsolateral prefrontal cortices (DLPFC) correlated significantly to the lifetime number of manic episodes. No association between local grey matter volume and the lifetime number of depression episodes or illness duration was found.
Conclusion: We found strong evidence for a linear correlation between a decrease in DLPFC volume and the lifetime number of manic episodes in patients with bipolar I disorder. Interestingly, DLPFC is known to be important for executive functions and the findings in this study might hence be linked to the executive cognitive deficits associated with bipolar disorder.