Reproduction among 1975 Sardinian women and men diagnosed with major mood disorders
Article first published online: 11 JAN 2011
© 2011 John Wiley & Sons A/S
Acta Psychiatrica Scandinavica
Volume 123, Issue 4, pages 283–289, April 2011
How to Cite
Tondo, L., Lepri, B. and Baldessarini, R. J. (2011), Reproduction among 1975 Sardinian women and men diagnosed with major mood disorders. Acta Psychiatrica Scandinavica, 123: 283–289. doi: 10.1111/j.1600-0447.2010.01660.x
- Issue published online: 6 MAR 2011
- Article first published online: 11 JAN 2011
- Accepted for publication November 26, 2010
Tondo L, Lepri B, Baldessarini RJ. Reproduction among 1975 Sardinian women and men diagnosed with major mood disorders.
Objective: Disability varies in patients with major affective disorders [type I and II bipolar disorders (BPD) and recurrent unipolar major depressive disorder (UP-MDD)]. It may include reproductive functioning, which has rarely been studied systematically.
Method: We compared information acquired over several years pertaining to marital/reproductive status among 1975 systematically evaluated, treated, and followed women (n = 1351) and men (n = 624) diagnosed with DSM-IV type I (n = 300) or II BPD (n = 223), or MDD (n = 1452). We compared factors between patients with vs. without children and associated with fertility rate (children/fertile years × 100), using standard bivariate methods followed by multivariate modeling.
Results: Childless patients were younger at illness onset, more likely men, diagnosed with type I BPD, more educated, and unmarried, but similar in many aspects of clinical history to those with children. Fertility rate ranked: BP-I < BP-II ≤ MDD, and men < women. Mood-disorder patients had 17% fewer children/person than in the comparable general population of Sardinia. Among mood-disorder patients, fertility appeared to decline in Sardinia in recent decades, more in men than women.
Conclusion: Type I BPD was associated with lower fertility than BP-II or UP-MDD, consistent with their relatively high levels of other disabilities.