Drs Bluhm and Frewen contributed equally to this manuscript.
Neural correlates of self-reflection in post-traumatic stress disorder
Version of Record online: 18 OCT 2011
© 2011 John Wiley & Sons A/S
Acta Psychiatrica Scandinavica
Volume 125, Issue 3, pages 238–246, March 2012
How to Cite
Bluhm, R. L., Frewen, P. A., Coupland, N. C., Densmore, M., Schore, A. N. and Lanius, R. A. (2012), Neural correlates of self-reflection in post-traumatic stress disorder. Acta Psychiatrica Scandinavica, 125: 238–246. doi: 10.1111/j.1600-0447.2011.01773.x
- Issue online: 10 FEB 2012
- Version of Record online: 18 OCT 2011
- Accepted for publication September 2, 2011
- self-referential processing;
- post-traumatic stress disorder;
- medial prefrontal cortex;
- posterior cingulate cortex
Bluhm RL, Frewen PA, Coupland NC, Densmore M, Schore AN, Lanius RA. Neural correlates of self-reflection in post-traumatic stress disorder.
Objective: Disturbances in self-referential processing (SRP) are increasingly recognized in post-traumatic stress disorder (PTSD). In healthy adults, SRP tasks engage the medial prefrontal cortex (MPFC) and posterior cingulate cortex (PCC) brain regions that have shown altered function in PTSD. We hypothesized that individuals with PTSD would differ from controls in functional activation of the MPFC and PCC during SRP.
Method: We compared neural activation in healthy controls (n = 15) and participants with PTSD (n = 20) during a SRP task, using fMRI at 4.0T.
Results: Controls made faster responses to the self-relevance of personal characteristics than to the accuracy of general facts, whereas response times did not differ between these conditions in PTSD. Controls also demonstrated greater MPFC (dorsal and ventral) and PCC response when considering the self-relevance of personal characteristics in comparison with the accuracy of general facts. Individuals with PTSD demonstrated less MPFC response than did healthy controls for the contrast of self-relevance of personal characteristics relative to general facts.
Conclusions: These results implicate MPFC in SRP disturbances associated with PTSD. These findings are relevant to current proposals for including symptoms of negative self-referential cognition and identity-existential disturbance as diagnostically relevant to PTSD.