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Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study

Authors

  • N. Fayed,

    1. Department of Radiology, Quirón Hospital, Zaragoza, Spain
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  • E. Andres,

    1. CIBER Epidemiology and Public Health, Clinic Epidemiology Unit, 12 de Octubre Hospital, Madrid, Spain
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  • G. Rojas,

    1. Department of Radiology, Quirón Hospital, Zaragoza, Spain
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  • S. Moreno,

    1. Department of Psychiatry, Aragonese Institute of Health Sciences, Miguel Servet Hospital and University of Zaragoza, Zaragoza, Spain
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    • Preventative Activities and Health Promotion Network (REDIAPP) (G06/170).

  • A. Serrano-Blanco,

    1. Sant Joan de Déu Health Parc & Sant Joan de Déu Foundation, Sant Boi de Llobregat, Barcelona, Spain
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    • Preventative Activities and Health Promotion Network (REDIAPP) (G06/170).

  • M. Roca,

    1. Health Sciences Research Universitary Institut, Juan March Hospital, Illes Balears University, Palma de Mallorca, Baleares, Spain
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    • Preventative Activities and Health Promotion Network (REDIAPP) (G06/170).

  • J. Garcia-Campayo

    1. Department of Psychiatry, Aragonese Institute of Health Sciences, Miguel Servet Hospital and University of Zaragoza, Zaragoza, Spain
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    • Preventative Activities and Health Promotion Network (REDIAPP) (G06/170).


Javier Garcia-Campayo, Department of Psychiatry, Miguel Servet University Hospital, Avda Isabel La Catolica 1, 50009 Zaragoza, Spain.
E-mail: jgarcamp@gmail.com

Abstract

Fayed N, Andres E, Rojas G, Moreno S, Serrano-Blanco A, Roca M, Garcia-Campayo J. Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study.

Objective:  To evaluate the brain metabolite patterns in patients with fibromyalgia (FM) and somatization disorder (STD) compared with healthy controls through spectroscopy techniques and correlate these patterns with psychological variables.

Method:  Design. Controlled, cross-sectional study. Sample. Patients were recruited from primary care in Zaragoza, Spain. The control group was recruited from hospital staff. Patients were administered questionnaires on pain catastrophizing, anxiety, depression, pain, quality of life, and cognitive impairment. All patients underwent Magnetic Resonance Imaging and magnetic resonance spectroscopy (MRS).

Results:  A significant increase was found in the glutamate + glutamine (Glx) levels in the posterior cingulate cortex (PCC): 10.73 (SD: 0.49) for FM and 9.67 (SD: 1.10) for STD 9.54 (SD: 1.46) compared with controls (= 0.043). In the FM + STD group, a correlation between Glx and pain catastrophizing in PCC (= 0.397; = 0.033) and between quality of life and the myo-inositol/creatine ratio in the left hippocampus (r = −0.500; = 0.025) was found. To conclude Glutamate seems to be relevant in the molecular processes involved in FM and STD. It also opens the door for Proton MRS (1H-MRS) in STD and suggests that reducing glutamatergic activity through pharmacological treatment could improve the outcome of patients with FM and STD.

Conclusion:  Glutamate seems to be relevant in the molecular processes involved in FM and STD. It also opens the door for Proton MRS (1H-MRS) in STD and suggests that reducing glutamatergic activity through pharmacological treatment could improve the outcome of patients with FM and STD.

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