C-reactive protein, early life stress, and wellbeing in healthy adults
Article first published online: 11 JUN 2012
© 2012 John Wiley & Sons A/S
Acta Psychiatrica Scandinavica
Volume 126, Issue 6, pages 402–410, December 2012
How to Cite
Carpenter, L. L., Gawuga, C. E., Tyrka, A. R. and Price, L. H. (2012), C-reactive protein, early life stress, and wellbeing in healthy adults. Acta Psychiatrica Scandinavica, 126: 402–410. doi: 10.1111/j.1600-0447.2012.01892.x
- Issue published online: 7 NOV 2012
- Article first published online: 11 JUN 2012
- Accepted for publication May 9, 2012
- C-reactive protein/analysis;
- mental health;
- health status;
- health surveys
Carpenter LL, Gawuga CE, Tyrka AR, Price LH. C-reactive protein, early life stress, and wellbeing in healthy adults.
Objective: To determine whether C-reactive protein (CRP) can serve as a marker for alterations in immune function prior to the manifestation of significant psychiatric and medical disorders.
Method: Ninety-two healthy adults were recruited from the community and determined to be free of psychiatric or medical disorders. The concentration of plasma CRP from a single resting sample was examined in relation to current mental and physical health as well as to self-reported history of early life adversity.
Results: C-reactive protein showed a significant positive correlation with body mass index (BMI; r = 0.477, P < 0.001). Non-specific pain, fatigue, and lower overall quality of physical health were all associated with higher CRP concentrations (all P < 0.05 or P < 0.01), after controlling for effect of BMI and other relevant covariates. Subthreshold depression symptoms and other indices of mental/emotional wellbeing were not associated with CRP, nor was CRP significantly linked to any measures of early life adversity.
Conclusion: Lower-quality physical health and wellbeing, but not the presence of mood/anxiety symptoms or early life stress (ELS), were significantly related to plasma CRP. Elevated CRP does not appear to be a fundamental consequence of ELS among healthy adults.