The Strauss and Carpenter Prognostic Scale in subjects clinically at high risk of psychosis
Article first published online: 7 JUL 2012
© 2012 John Wiley & Sons A/S
Acta Psychiatrica Scandinavica
Volume 127, Issue 1, pages 53–61, January 2013
How to Cite
Nieman, D. H., Velthorst, E., Becker, H. E., de Haan, L., Dingemans, P. M., Linszen, D. H., Birchwood, M., Patterson, P., Salokangas, R. K. R., Heinimaa, M., Heinz, A., Juckel, G., von Reventlow, H. G., Morrison, A., Schultze-Lutter, F., Klosterkötter, J., Ruhrmann, S. and on behalf of the EPOS group (2013), The Strauss and Carpenter Prognostic Scale in subjects clinically at high risk of psychosis. Acta Psychiatrica Scandinavica, 127: 53–61. doi: 10.1111/j.1600-0447.2012.01899.x
- Issue published online: 13 DEC 2012
- Article first published online: 7 JUL 2012
- Accepted for publication May 30, 2012
- prediction of psychosis;
- social functioning;
- clinically at high risk;
- Strauss and Carpenter Prognostic Scale
Objective: To investigate the predictive value of the Strauss and Carpenter Prognostic Scale (SCPS) for transition to a first psychotic episode in subjects clinically at high risk (CHR) of psychosis.
Method: Two hundred and forty-four CHR subjects participating in the European Prediction of Psychosis Study were assessed with the SCPS, an instrument that has been shown to predict outcome in patients with schizophrenia reliably.
Results: At 18-month follow-up, 37 participants had made the transition to psychosis. The SCPS total score was predictive of a first psychotic episode (P < 0.0001). SCPS items that remained as independent predictors in the Cox proportional hazard model were as follows: most usual quality of useful work in the past year (P = 0.006), quality of social relations (P = 0.006), presence of thought disorder, delusions or hallucinations in the past year (P = 0.001) and reported severity of subjective distress in past month (P = 0.003).
Conclusion: The SCPS could make a valuable contribution to a more accurate prediction of psychosis in CHR subjects as a second-step tool. SCPS items assessing quality of useful work and social relations, positive symptoms and subjective distress have predictive value for transition. Further research should focus on investigating whether targeted early interventions directed at the predictive domains may improve outcomes.