Elevated number of cells secreting transforming growth factor β in Guillain-Barré syndrome

Authors

  • C. DAHLE,

    Corresponding author
    1. Division of Neurology, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linköping University Hospital,
    2. Division of Clinical Immunology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University Hospital, and
      Charlotte Dahle, Division of Clinical Immunology, Linköping University Hospital, SE-581 85 Linköping, Sweden. e-mail: lotta.dahle@lio.se
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  • M. KVARNSTRÖM,

    1. Division of Clinical Immunology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University Hospital, and
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  • C. EKERFELT,

    1. Division of Clinical Immunology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University Hospital, and
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  • M. SAMUELSSON,

    1. Neurology unit, Örebro University Hospital, Sweden
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  • J. ERNERUDH

    1. Division of Neurology, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linköping University Hospital,
    2. Division of Clinical Immunology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University Hospital, and
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Charlotte Dahle, Division of Clinical Immunology, Linköping University Hospital, SE-581 85 Linköping, Sweden. e-mail: lotta.dahle@lio.se

Abstract

We used ELISPOT and cell ELISA to study secretion of IL-4, IFN-γ, TGF-β, IL-6, and TNF-α by circulating mononuclear cells during the course of Guillain-Barré syndrome (GBS). Compared to healthy controls, patients with GBS had higher numbers of TGF-β-secreting cells and the number of individuals with myelin-peptide-induced IL-4 and TGF-β secretion was higher in the GBS group. No significant differences were seen concerning the predominantly pro-inflammatory cytokines IFN-γ, IL-6 or TNF-α. Our findings indicate a down-regulatory role for TGF-β and IL-4 in GBS.

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