Granulocytic sarcoma presenting with lymph node infarction at disease onset
Report of two cases
Article first published online: 16 DEC 2003
Volume 111, Issue 12, pages 1133–1136, December 2003
How to Cite
KOJIMA, M., NAKAMURA, S., SHIMIZU, K., YAMANE, Y., ITOH, H. and MASAWA, N. (2003), Granulocytic sarcoma presenting with lymph node infarction at disease onset. APMIS, 111: 1133–1136. doi: 10.1111/j.1600-0463.2003.apm1111209.x
- Issue published online: 16 DEC 2003
- Article first published online: 16 DEC 2003
- Received June 7, 2003.; Accepted October 14, 2003.
- Acute myeloid leukemia;
- granulocytic sarcoma;
- lymph node;
A completely infarcted lymph node is an unusual event. However, lymph node infarction should alert the pathologist to the considerable likelihood of malignant lymphoma. We report two unusual cases of acute myeloid leukemia presenting with granulocytic sarcoma at disease onset with a lymph node lesion exhibiting extensive lymph node infarction. The infarcted tissue contained numerous eosinophilic cell ghosts. There were some islands of degenerated, pyknotic medium-sized nuclei resembling lymphoblasts present in the necrotic area. By immunohistochemistry, these medium sized cells were CD3−, CD20−, CD34+, CD43+, CD45RO−, CD68−, CD79a− and myeloperoxidase+ in both cases. Differentiation of granulocytic sarcoma from malignant lymphomas is important for adequate therapy. The present cases indicate that granulocytic sarcoma should be added to the list of differential diagnoses for lymph node infarction.