SEARCH

SEARCH BY CITATION

REFERENCES

  • 1
    Taub R . Liver regeneration. From myth to mechanism. Nat Rev Mol Cell Biol 2004;5: 83647.
  • 2
    Fausto N , Campbell JS . The role of hepatocytes and oval cells in liver regeneration and repopulation. Mech Dev 2003;120: 11730.
  • 3
    Fausto N . Liver regeneration. J Hepatol 2000;32: 1931.
  • 4
    Michalopoulos GK , DeFrances MC . Liver regeneration. Science 1997;276: 606.
  • 5
    Higgins GM , Anderson RM . Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931;12: 186202.
  • 6
    Yin L , Lynch D , Ilic Z , Sell S . Proliferation and differentiation of ductular progenitor cells and littoral cells during regeneration of the rat liver to CCl4/2-AAF injury. Histol Histopathol 2002;17: 6581.
  • 7
    Lee VM , Cameron RG , Archer MC . Zonal location of compensatory hepatocyte proliferation following induced hepatotoxicity in rats and human. Toxicol Pathol 1998;26: 6217.
  • 8
    Lemire JM , Shiojiri N , Fausto N . Oval cell proliferation and the origin of hepatocytes in liver injury induced by D-galactosamine. Am J Pathol 1991;139: 53552.
  • 9
    Dabeva MD , Shafritz DA . Activation, proliferation, and differentiation of progenitor cells into hepatocytes in the D-galactosamine model of liver regeneration. Am J Pathol 1993;143: 160620.
  • 10
    Yavorkovsky L , Lai E , Ilic Z , Sell S . Participation of small intraportal stem cells in the restitutive response of the liver to periportal necrosis induced by allyl alcohol. Hepatology 1995;21: 170212.
  • 11
    Shinozuka H , Lombardi B , Sell S , Iammarino RM . Early histological and functional alterations of ethionine liver carcinogenesis in rats fed a choline-deficient diet. Cancer Res 1978;38: 10927.
  • 12
    Evarts RP , Nagy P , Marsden E , Thorgeirsson SS . A precursor-product relationship exists between oval cells and hepatocytes in rat liver. Carcinogenesis 1987;8: 173740.
  • 13
    Petersen BE , Zajac VF , Michalopoulos GK . Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats. Hepatology 1998;27: 10308.
  • 14
    Sell S , Leffert HL , Shinozuka H , Lombardi B , Gochman N . Rapid development of large numbers of α-fetoprotein-containing “oval” cells in the liver of rats fed N-2-fluorenylacetamide in a choline-devoid diet. Gann 1981;72: 47987.
  • 15
    Smith PGJ , Tee LBG , Yeoh GC . Appearance of oval cells in the liver of rats after long-term exposure to ethanol. Hepatology 1996;23: 14554.
  • 16
    Dabeva MD , Laconi E , Oren R , Petkov PM , Hurston E , Shafritz DA . Liver regeneration and α-fetoprotein messenger RNA expression in the retrorsine model for hepatocyte transplantation. Cancer Res 1998;58: 582534.
  • 17
    Gordon GJ , Coleman WB , Hixson DC , Grisham JW . Liver regeneration in rats with retrorsine-induced hepatocellular injury proceeds through a novel cellular response. Am J Pathol 2000;156: 60619.
  • 18
    Koniaris LG , Zimmers-Koniaris T , Hsiao EC , Chavin K , Sitzmann JV , Farber JM . Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration. J Immunol 2001;167: 399406.
  • 19
    Lee JH , Ilic Z , Sell S . Cell kinetics of repair after allyl alcohol-induced liver necrosis in mice. Int J Exp Path 1996;77: 6372.
  • 20
    Engelhardt NV , Baranov MN , Goussev AI . Ultrastructural localisation of α-fetoprotein (AFP) in regenerating mouse liver poisoned with CCL4. Reexpression of AFP in differentiated hepatocytes. Histochemistry 1984;80: 4017.
  • 21
    Kofman AV , Morgan G , Kirschenbaum A , Osbeck J , Hussain M , Swenson S , Theise ND . Dose- and time-dependent oval cell reaction in acetaminophen-induced murine liver injury. Hepatology 2005;41: 125261.
  • 22
    Akhurst B , Croager EJ , Farley-Roche CA , Ong JK , Dumble ML , Knight B , Yeoh GC . A Modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver. Hepatology 2001;34: 51922.
  • 23
    Preisegger K , Factor VM , Fuchsbichler A , Stumptner C , Denk H , Thorgeirsson SS . Atypical ductular proliferation and its inhibition by transforming growth factor β1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease. Lab Invest 1999;79: 1039.
  • 24
    Wang X , Foster M , Al-Dhalimy M , Lagasse E , Finegold M , Grompe M . The origin and liver repopulating capacity of murine oval cells. Proc Natl Acad Sci USA 2003;100: 118818.
  • 25
    Roskams T , Yang SQ , Koteish A , Durnez A , DeVos R , Huang X , Achten R , Verslype C , Diehl AM . Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease. Am J Pathol 2003;63: 130111.
  • 26
    Factor VM , Radaeva SA , Thorgeirsson SS . Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. Am J Pathol 1994;45: 40922.
  • 27
    Van Thiel DH , Gavaler JS , Kam I , Francavilla A , Polimeno L , Schade RR , Smith J , Diven W , Penkrot RJ , Starzl TE . Rapid growth of an intact human liver transplanted into a recipient larger than the donor. Gastroenterology 1987;93: 14149.
  • 28
    Desmet V , Roskams T , Van Eyken P . Ductular reaction in the liver. Path Res Pract 1995;191: 51324.
  • 29
    Sell S . Comparison of liver progenitor cells in human atypical ductular reactions with those seen in experimental models of liver injury. Hepatology 1998;27: 31731.
  • 30
    Roskams TA , Libbrecht L , Desmet VJ . Progenitor cells in diseased human liver. Semin Liver Dis 2003;23: 38596.
  • 31
    Roskams TA , Theise ND , Balabaud C , Bhagat G , Bhathal PS , Bioulac-Sage P , Brunt EM , Crawford JM , Crosby HA , Desmet V , Finegold MJ , Geller SA , Gouw ASH , Hytiroglou P , Knisely AS , Kojiro M , Lefkowitch JH , Nakanuma Y , Olynyk JK , Park YN , Portmann B , Saxena R , Scheuer PJ , Strain AJ , Thung SN , Wanless IR , West AB . Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology 2004;39: 173945.
  • 32
    Koniaris LG , McKillop ICH , Schwartz SI , Zimmers TA . Liver regeneration. J Am Coll Surg 2003;197: 63459.
  • 33
    Overturf K , Al-Dhalimy M , Ou C , Grompe M . Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol 1997;51: 127380.
  • 34
    Dabeva MD , Shafritz DA . Hepatic stem cells and liver repopulation. Semin Liver Dis 2003;23: 34962.
  • 35
    Michalopoulos GK , Barau L , Bowen WC . Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology 2005;41: 53544.
  • 36
    Ferrell L . Liver pathology: cirrhosis, hepatitis, and primary liver tumours: update and diagnostic problems. Mod Pathol 2000;13: 679704.
  • 37
    Nagy P , Teramoto T , Factor VM , Sanchez A , Schnur J , Paku S , Thorgeirsson SS . Reconstitution of liver mass via cellular hypertrophy in the rat. Hepatology 2001;33: 33945.
  • 38
    Kinosita R . Studies on the cancerogenic chemical substances. Trans Soc Pathol Jpn 1937;27: 665727.
  • 39
    Farber E . Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3′-methyl-4-dimethylaminoazobenzene. Cancer Res 1956;16: 1428.
  • 40
    Wilson JW , Leduc EH . Role of cholangioles in restoration of the liver of the mouse after dietary injury. J Path Bact 1958;LXXVI: 4419.
  • 41
    Paku S , Schnur J , Nagy P , Thorgeirsson SS . Origin and structural evolution of the early proliferating oval cells in rat liver. Am J Pathol 2001;158: 131323.
  • 42
    Petersen BE , Zajac VF , Michalopoulos GK . Bile ductular damage induced by methylene dianiline inhibits oval cell activation. Am J Pathol 1997;151: 9059.
  • 43
    Petersen BE , Bowen WC , Patrene KD , Mars WM , Sullivan AK , Murase N , Boggs SS , Greenberger JS , Goff JP . Bone marrow as a potential source of hepatic oval cells. Science 1999;284: 116870.
  • 44
    Lagasse E , Connors H , Al-Dhalimy M , Reitsma M , Dohse M , Osborne L , Wang X , Finegold M , Weissman IL , Grompe M . Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000;6: 12123.
  • 45
    Theise ND , Badve S , Saxena R , Henegariu O , Sell S , Crawford JM , Krause DS . Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology 2000;31: 23540.
  • 46
    Theise N , Nimmakayalu M , Gardner R , Illei PB , Morgan G , Teperman L , Henegariu O , Krause DS . Liver from bone marrow in humans. Hepatology 2000;32: 116.
  • 47
    Alison MR , Poulsom R , Jeffery R , Dhillon AP , Quaglia A , Jacob J , Novelli M , Prentice G , Williamson J , Wright NA . Hepatocytes from non-hepatic adult stem cells. Nature 2000;406: 257.
  • 48
    Korbling M , Katz Khanna A , Ruifrok AC , Rondon G , Albitar M , Champlin RE , Estrov Z . Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med 2002;346: 73846.
  • 49
    Wang X , Montini E , Al-Dhalimy M , Lagasse E , Finegold M , Grompe M . Kinetics of liver repopulation after bone marrow transplantation. Am J Pathol 2002;161: 56574.
  • 50
    Vassilopoulos G , Wang PR , Russel DW . Transplanted bone marrow regenerates liver cells by fusion. Nature 2003;422: 9014.
  • 51
    Wang X , Willenbring H , Akkari Y , Torimaru Y , Foster M , Al-Dhalimy M , Lagasse E , Finegold M , Olson S , Grompe M . Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 2003;422: 897901.
  • 52
    Grompe M . Bone marrow-derived hepatocytes. Novartis Found Symp 2005;265: 207.
  • 53
    Menthena A , Deb N , Oertel M , Grozdanov PN , Sandhu J , Shah S , Shafritz DA , Dabeva M . Bone marrow progenitors are not the source of expanding oval cells in injured liver. Stem Cells 2004;22: 104961.
  • 54
    Tee LBG , Smith PGJ , Yeoh GC . Expression of α, μ and π class glutathione S-transferases in oval and ductal cells in liver of rats placed on a choline-deficient, ethionine-supplemented diet. Carcinogenesis 1992;13: 187985.
  • 55
    Cameron R , Kellen J , Kolin A , Malkin A , Farber E . γ-Glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis. Cancer Res 1978;38: 8239.
  • 56
    Bisgaard HC , Parmelee DC , Dunsford HA , Sechi S , Thorgeirsson SS . Keratin 14 protein in cultured nonparenchymal rat hepatic epithelial cells: characterization of keratin 14 and keratin 19 as antigens for the commonly used mouse monoclonal antibody OV-6. Mol Carcinogenesis 1993;7: 606.
  • 57
    Paku S , Dezs K , Kopper L , Nagy P . Immunohistochemical analysis of cytokeratin 7 expression in resting and proliferating biliary structures of rat liver. Hepatology 2005;42: 86370.
  • 58
    Lowes KN , Brennan BA , Yeoh GC , Olynyk JK . Oval cell numbers in human chronic liver diseases are directly related to disease severity. Am J Pathol 1999;154: 53741.
  • 59
    Dunsford HA , Sell S . Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and transplantable Morris hepatomas. Cancer Res 1989;49: 488793.
  • 60
    Engelhardt NV , Factor VM , Medvinsky AL , Baranov VN , Lazareva MN , Poltoranina VS . Common antigen of oval and biliary epithelial cells (A6) is a differentiation marker of epithelial and erythroid cell lineages in early development of the mouse. Differentation 1993;55: 1926.
  • 61
    Hixson DC , Allison JP . Monoclonal antibodies recognizing oval cells induced in the liver of rats by N-2-flourenylacetamide or ethionine in a choline-deficient diet. Cancer Res 1985;45: 375060.
  • 62
    Zhang M , Thorgeirsson SS . Modulation of connexins during differentiation of oval cells into hepatocytes. Exp Cell Res 1994;213: 3742.
  • 63
    Fujio K , Evarts RP , Hu Z , Madsen ER , Thorgeirsson SS . Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat. Lab Invest 1994;70: 5116.
  • 64
    Fujio K , Hu Z , Evarts RP , Marsden ER , Niu CH , Thorgeirsson SS . Coexpression of stem cell factor and c-kit in embryonic and adult liver. Exp Cell Res 1996;224: 24350.
  • 65
    Omori N , Omori M , Evarts RP , Teramoto T , Miller MJ , Hoang TN , Thorgeirsson SS . Partial cloning of rat CD34 cDNA and expression during stem cell-dependent liver regeneration in adult rat. Hepatology 1997;26: 7207.
  • 66
    Bisgaard HC , Holmskov U , Santoni-Rugiu E , Nagy P , Nielsen O , Ott P , Hage E , Dalhoff K , Rasmussen LJ , Tygstrup N . Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor 1. Am J Pathol 2002;161: 118798.
  • 67
    Mavier P , Martin N , Couchie D , Préaux A , Laperche Y , Zafrani ES . Expression of stromal cell-derived factor-1 and of its receptor CXCR4 in liver regeneration from oval cells in rat. Am J Pathol 2004;165: 196977.
  • 68
    Evarts RP , Nagy P , Marsden E , Thorgeirsson SS . In situ hybridization studies on expression of albumin and alpha-fetoprotein during the early stage of neoplastic transformation in rat liver. Cancer Res 1987;47: 546975.
  • 69
    Tanimizu N , Tsujimura T , Takahide K , Kodama T , Nakamura K , Miyajima A . Expression of Dlk/Pref-1 defines a subpopulation in the oval cell compartment of rat liver. GEP 2004;5: 2098.
  • 70
    Jensen CH , Jauho EI , Santoni-Rugiu E , Holmskov U , Teisner B , Tygstrup N , Bisgaard HC . Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1. Am J Pathol 2004;164: 134759.
  • 71
    Lamas E , Kahn A , Guillouzo A . Detection of mRNAs present at low concentration in rat liver by in situ hybridization: application to the study of metabolic regulation and azo-dye hepatocarcinogenesis. J Histochem Cytochem 1987;35: 55963.
  • 72
    Skala H , Vibert M , Lamas E , Maire P , Schweighoffer F , Kahn A . Molecular cloning and expression of rat aldolase C messenger RNA during development and hepatocarcinogenesis. Eur J Biochem 1987;163: 5138.
  • 73
    Hu Z , Evarts RP , Fujio K , Marsden ER , Thorgeirsson SS . Expression of hepatocyte growth factor and c-met genes during hepatic differentiation and liver development in the rat. Am J Pathol 1993;142: 182330.
  • 74
    Hu Z , Evarts RP , Fujio K , Omori N , Omori M , Marsden ER , Thorgeirsson SS . Expression of transforming growth factor α/epidermal growth factor receptor, hepatocyte growth factor/c-met and acidic fibroblast growth factor/fibroblast growth factor receptors during hepatocarcinogenesis. Carcinogenesis 1996;17: 9318.
  • 75
    Petersen BE , Goff JP , Greenberger JS , Michalopoulos GK . Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in rat. Hepatology 1998;27: 43345.
  • 76
    Hatch HM , Zheng D , Jorgensen ML , Petersen BE . SDF-1α/CXCR4. A mechanism for hepatic oval cell activation and bone marrow stem cell recruitment to the injured liver of rats. Cloning Stem Cells 2002;4: 33951.
  • 77
    Tian Y , Smith PGJ , Yeoh GC . The oval-shaped cell as a candidate for a liver stem cell in embryonic, neonatal and precancerous liver: identification based on morphology and immunohistochemical staining for albumin and pyruvate kinase isoenzyme expression. Histochem Cell Biol 1997;107: 24350.
  • 78
    Gauldie J , Lamontagne L , Horsewood P , Jenkins E . Immunohistochemical localization of alpha 1-antitrypsin in normal mouse liver and pancreas. Am J Pathol 1980;101: 72335.
  • 79
    Nagy P , Bisgaard HC , Thorgeirsson SS . Expression of hepatic transcription factors during liver development and oval cell differentiation. J Cell Biol 1994;126: 22333.
  • 80
    Faris RA , Monfils BA , Dunsford HA , Hixson DC . Antigenic relationship between oval cells and a subpopulation of hepatic foci, nodules, and carcinomas induced by the “resistant hepatocyte” model system. Cancer Res 1991;51: 130817.
  • 81
    Hixson DC , Chapman L , McBride A , Faris R , Yang L . Antigenic phenotypes common to rat oval cells, primary hepatocellular carcinomas and developing bile ducts. Carcinogenesis 1997;18: 116975.
  • 82
    Petropoulos C , Andrewa G , Tamaoki T , Fausto N . α-Fetoprotein and albumin mRNA levels in liver regeneration and carcinogenesis. J Biol Chem 1983;258: 49016.
  • 83
    Petropoulos CJ , Yaswen P , Panzica M , Fausto N . Cell lineages in liver carcinogenesis: possible clues from studies of the distribution of alpha-fetoprotein RNA sequences in cell populations isolated from normal, regenerating, and preneoplastic rat livers. Cancer Res 1985;45: 57628.
  • 84
    Bisgaard HC , Nagy P , Ton PT , Hu Z , Thorgeirsson SS . Modulation of keratin 14 and α-fetoprotein expression during hepatic oval cell proliferation and liver regeneration. J Cell Phys 1994;159: 47584.
  • 85
    Bisgaard HC , Nagy P , Santoni-Rugiu E , Thorgeirsson SS . Proliferation, apoptosis, and induction of hepatic transcription factors are characteristics of the early response of biliary epithelial (oval) cells to chemical carcinogens. Hepatology 1996;23: 5270.
  • 86
    Knight B , Yeoh GC , Husk KL , Ly T , Abraham LJ , Yu C , Rhim JA , Fausto N . Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice. J Exp Med 2000;192: 180918.
  • 87
    Paku S , Nagy P , Kopper L , Thorgeirsson SS . 2-Acetylaminofluorene dose-dependent differentiation of rat oval cells into hepatocytes: confocal and electron microscopic studies. Hepatology 2004;39: 135361.
  • 88
    Smas CM , Sul HS . Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 1993;73: 72534.
  • 89
    Bauer SR , Ruiz-Hidalgo MJ , Rudikoff EK , Goldstein J , Laborda J . Modulated expression of the epidermal growth factor-like homeotic protein dlk influences stromal-cell-pre-B-cell interactions, stromal cell adipogenesis, and pre-B-cell interleukin-7 requirements. Mol Cell Biol 1998;18: 524755.
  • 90
    Moore KA , Pytowski B , Witte L , Hicklin D , Lemischka IR . Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs. Proc Natl Acad Sci USA 1997;94: 40116.
  • 91
    Halder SK , Takemori H , Hatano O , Nonaka Y , Wada A , Okamoto M . Cloning of a membrane-spanning protein with epidermal growth factor-like repeat motifs from adrenal glomerulosa cells. Endocrinology 1998;139: 331628.
  • 92
    Tanimizu N , Nishikawa M , Saito H , Tsujimura T , Miyajima A . Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J Cell Sci 2003;116: 177586.
  • 93
    Petersen BE , Grossbard B , Hatch H , Pi L , Deng J , Scott EW . Mouse A6-positive hepatic oval cells also express several hematopoietic stem cell markers. Hepatology 2003;37: 63240.
  • 94
    Theise ND , Saxena R , Portmann BC , Thung SN , Yee H , Chiriboga L , Kumar A , Crawford JM . The canals of Hering and hepatic stem cells in humans. Hepatology 1999;30: 142533.
  • 95
    Libbrecht L , Cassiman D , Desmet V , Roskams T . Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases. Histochem Cell Biol 2001;116: 2339.
  • 96
    Libbrecht L , Desmet V , Van Damme B , Roskams T . Deep intralobular extension of human hepatic “progenitor cells” correlates with parenchymal inflammation in chronic viral hepatitis: can “progenitor cells” migrate? J Pathol 2000;192: 3738.
  • 97
    Falkowski O , An HJ , Ianus IA , Chiriboga L , Yee H , West AB , Theise ND . Regeneration of hepatocyte ‘buds’ in cirrhosis from intrabiliary stem cells. J Hepatol 2003;39: 35764.
  • 98
    Thorgeirsson SS , Grisham JW . Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002;31: 33946.
  • 99
    Imoto M , Nishimura D , Fukuda Y , Sugiyama K , Kumada T , Nakano S . Immunohistochemical detection of α-fetoprotein, carcinoembryonic antigen, and ferritin in formalin-paraffin sections from hepatocellular carcinoma. Am J Gastroenterol 1985;80: 9026.
  • 100
    Ruck P , Xiao JC , Pietch T , Schweinitz V , Kaiserling E . Hepatic stem-like cells in hepatoblastoma: expression of cytokeratin 7, albumin and oval cell associated antigens detected by OV-1 and OV-6. Histopathology 1997;31: 3249.
  • 101
    Wu PC , Lai VC , Fang JW , Gerber MA , Lai CL , Lau JY . Hepatocellular carcinoma expressing both hepatocellular and biliary markers also express cytokeratin 14, a marker of bipotential progenitor cells. J Hepatol 1999;31: 9656.
  • 102
    Libbrecht L , Desmet V , Van Damme B , Roskams T . The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells. J Hepatol 2000;33: 7684.
  • 103
    Zimmermann A . Hepatoblastoma with cholangioblastic features (“cholangioblastic hepatoblastoma”) and other liver tumors with bimodal differentiation in young patients. Med Pediatric Oncol 2002;39: 48791.
  • 104
    Kojiro M , Roskams T . Early hepatocellular carcinoma and dysplastic nodules. Semin Liver Dis 2005;25: 13342.
  • 105
    Evarts RP , Nakatsukasa H , Marsden ER , Hsia CC , Dunsford HA , Thorgeirsson SS . Cellular and molecular changes in the early stages of chemical hepatocarcinogenesis in the rat. Cancer Res 1990;50: 343944.
  • 106
    Fausto N , Lemire JM , Shiojiri N . Oval cells in liver carcinogenesis: cell lineages in hepatic development and the identification of facultative stem cells in normal liver. In : SiricaAE editor. The Role of Cell Types in Hepatocarcinogenesis. Boca Raton: CRC Press, 1992.
  • 107
    Bennoun M , Rissel M , Engelhardt Guillouzo A , Briand P , Weber-Benarous A . Oval cell proliferation in early stages of hepatocarcinogenesis in simian virus large T antigen transgenic mice. Am J Pathol 1993;143: 132636.
  • 108
    Santoni-Rugiu E , Nagy P , Jensen MR , Factor VM , Thorgeirsson SS . Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-α. Am J Pathol 1996;149: 40728.
  • 109
    Dumble ML , Croager EJ , Yeoh GC , Quail EA . Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma. Carcinogenesis 2002;23: 43545.
  • 110
    Nagy P , Bisgaard HC , Santoni-Rugiu E , Thorgeirsson SS . In vivo infusion of growth factors enhances the mitogenic response of rat hepatic ductal (oval) cells after administration of 2-acetylaminofluorene. Hepatology 1996;23: 719.
  • 111
    Cornell RP , Liljequist BL , Bartizal KF . Depressed liver regeneration after partial hepatectomy of germ-free, athymic and lipopolysaccharide-resistant mice. Hepatology 1990;11: 91622.
  • 112
    Ishiyama H , Hoglen NC , Sipes IG . Diethyldithiocarbamate enhances production of nitric oxide and TNF-α by lipopolysaccharide-stimulated rat Kupffer cells. Toxicol Sci 2000;55: 20614.
  • 113
    Strey CW , Markiewski M , Mastellos D , Tudoran R , Spruce LA , Greenbaum LE , Lambris JD . The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med 2003;198: 91323.
  • 114
    Yamada Y , Kirillova I , Peschon JJ , Fausto N . Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci USA 1997;94: 14414.
  • 115
    Levy DE , Lee C . What does Stat3 do? J Clin Invest 2002;109: 11438.
  • 116
    May P , Schniertshauer U , Gerhartz C , Horn F , Heinrich PC . Signal transducer and activator of transcription STAT3 plays a major role in gp130-mediated acute phase protein gene activation. Acta Biochim Pol 2003;50: 595601.
  • 117
    Matthews VB , Klinken E , Yeoh GC . Direct effects of interleukin-6 on liver progenitor oval cells in culture. Wound Rep Reg 2004;12: 6506.
  • 118
    Nagy P , Kiss A , Schnur J , Thorgeirsson SS . Dexamethasone inhibits the proliferation of hepatocytes and oval cells but not bile duct cells in rat liver. Hepatology 1998;28: 42349.
  • 119
    Lee CM , Yeoh GC , Olynyk JK . Differential effects of gadolinium chloride on Kupffer cells in vivo and in vitro. Int J Biochem Cell Biol 2004;36: 4818.
  • 120
    Olynyk J , Yeoh GC , Ramm GA , Clarke SL , Hall PDLM , Britton RS , Bacon BR , Tracy TF . Gadolinium chloride suppresses hepatic oval cell proliferation in rats with biliary obstruction. Am J Pathol 1998;152: 34752.
  • 121
    Liu Z , Sakamato T , Yokomuro S , Ezure T , Subbotin V , Murase N , Contrucci S , Demetris AJ . Acute obstructive cholangiopathy in interleukin-6 deficient mice: compensation by leukaemia inhibitory factor (LIF) suggests importance of gp-130 signaling in the ductular reaction. Liver 2000;20: 11424.
  • 122
    Sanchez A , Factor VM , Schroeder IS , Nagy P , Thorgeirsson SS . Activation of NF-Kappaβ and STAT3 in rat oval cells during 2-acetylaminofluorene/partial hepatectomy induced regeneration. Hepatology 2004;39: 37685.
  • 123
    Taga T , Kishimoto T . Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 1997;15: 797819.
  • 124
    Heinrich PC , Behrmann I , Haan S , Hermanns HM , Muller-Newen G , Schaper F . Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003;374: 120.
  • 125
    Kuropatwinski KK , De Imus C , Gearing D , Baumann H , Mosley B . Influence of subunit combinations on signaling by receptors for oncostatin M, leukemia inhibitory factor, and interleukin-6. J Biol Chem 1997;272: 1513544.
  • 126
    Kinoshita T , Sekiguchi T , Xu MJ , Ito Y , Kamiya A , Tsuji K , Nakahata T , Miyajima A . Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis. Proc Natl Acad Sci USA 1999;96: 726570.
  • 127
    Nakamura K , Nonaka H , Saito H , Tanaka M , Miyajima A . Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice. Hepatology 2004;39: 63544.
  • 128
    Omori N , Evarts RP , Omori M , Hu Z , Marsden ER , Thorgeirsson SS . Expression of leukemia inhibitory factor and its receptor during liver regeneration in the adult rat. Lab Invest 1996;75: 1524.
  • 129
    Kamiya A , Kinoshita T , Ito Y , Matsui T , Morikawa Y , Senba E , Nakashima K , Taga T , Yoshida K , Kishimoto T , Miyajima A . Fetal liver development requires a paracrine action of on-costatin M through the gp130 signal transducer. EMBO J 1999;18: 212736.
  • 130
    Lázaro CA , Croager EJ , Mitchell C , Campbell JS , Yu C , Foraker J , Rhim JA , Yeoh GC , Fausto N . Establishment, characterization, and long-term maintenance of cultures of human fetal hepatocytes. Hepatology 2003;38: 1095106.
  • 131
    Okaya A , Kitanaka J , Kitanaka N , Satake M , Kim Y , Terada K , Sugiyama T , Takemura M , Fujimoto J , Terada N , Miyajima A , Tsujimura T . Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes. Am J Pathol 2005;166: 70919.
  • 132
    Suzuki A , Iwama A , Miyashita H , Nakauchi H , Taniguchi H . Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells. Development 2003;130: 251324.
  • 133
    Matthews VB , Knight B , Tirnitz-Parker JEE , Boon J , Olynyk JK , Yeoh GC . Oncostatin M induces an acute phase response but does not modulate the growth or maturation-status of liver progenitor (oval) cells in culture. Exp Cell Res 2005;306: 25263.
  • 134
    Znoyko I , Sohara N , Spicer S , Trjanowska M , Reuben A . Expression of oncostatin M and its receptors in normal and cirrhotic human liver. J Hepatol 2005;43: 893900.
  • 135
    Znoyko I , Sohara N , Spicer S , Trjanowska M , Reuben A . Comparative studies of oncostatin M expression in the tissues of adult rodents. Anat Rec A Discov Mol Cell Evol Biol 2005;283: 1826.
  • 136
    Michalopoulos G . Hepatocyte growth factor in liver growth and differentiation. In : StrainAJ , DiehlAM editors. Liver Growth and Repair. 1st ed. London: Chapman & Hall Ltd., 1998: 21939.
  • 137
    Stella MC , Comoglio PM . HGF: a multifunctional growth factor controlling cell scattering. Int J Biochem Cell Biol 1999;31: 135762.
  • 138
    Mars WM , Kim T , Stolz DB , Liu M , Michalopoulos GK . Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor. Cancer Res 1996;56: 283743.
  • 139
    Pediaditakis P , Monga SPS , Mars WM , Michalopoulos GK . Differential mitogenic effects of single chain hepatocyte growth factor (HGF)/scatter factor and HGF/NK1 following cleavage by factor Xa. J Biol Chem 2002;277: 1410915.
  • 140
    Schmidt C , Bladt F , Goedecke S , Brinkmann V , Zschiesche W , Sharpe M , Gherardi E , Birchmeier C . Scatter factor/hepatocyte growth factor is essential for liver development. Nature 1995;373: 699702.
  • 141
    Huh CG , Factor VM , Sanchez A , Uchida K , Conner EA , Thorgeirsson SS . Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A 2004;101: 447782.
  • 142
    Kim WH , Matsumoto K , Bessho K , Nakamura T . Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Am J Pathol 2005;1017: 28.
  • 143
    Shiota G , Okano J , Kawasaki H , Kawamoto T , Nakamura T . Serum hepatocyte growth factor levels in liver diseases: clinical implications. Hepatology 1995;21: 10612.
  • 144
    Shiota G , Wang TC , Nakamura T , Schmidt EV . Hepatocyte growth factor in transgenic mice: effects on hepatocyte growth, liver regeneration and gene expression. Hepatology 1994;19: 96272.
  • 145
    Webber EM , Godowski PJ , Fausto N . In vivo response of hepatocytes to growth factors requires an initial priming stimulus. Hepatology 1994;19: 48997.
  • 146
    Salomon DS , Kim N , Saeki T , Ciardiello F . Transforming growth factor-α: an oncodevelopmental growth factor. Cancer Cells 1990;2: 38997.
  • 147
    Russel WE , Carver RS . The EGF/TGFα family of growth factors and their receptors. In : StrainAJ , DiehlAM editors. Liver Growth and Repair. 1st ed. London: Chapman & Hall Ltd., 1998: 185218.
  • 148
    Evarts RP , Nakatsukasa H , Marsden ER , Hu Z , Thorgeirsson SS . Expression of transforming growth factor-α in regenerating liver and during hepatic differentiation. Mol Carcinog 1992;5: 2531.
  • 149
    Webber EM , FitzGerald MJ , Brown PI , Bartlett MH , Fausto N . Transforming growth factor-α expression during liver regeneration after partial hepatectomy, and toxic injury, and potential interactions between transforming growth factor-α and hepatocyte growth factor. Hepatology 1993;18: 142231.
  • 150
    Webber EM , Wu JC , Wang L , Merlino G , Fausto N . Overexpression of transforming growth factor-α causes liver enlargement and increased hepatocyte proliferation in transgenic mice. Am J Pathol 1994;145: 398408.
  • 151
    Marsden ER , Hu Z , Fujio K , Nakatsukasa H , Thorgeirsson SS , Evarts RP . Expression of acidic fibroblast growth factor in regenerating liver and during hepatic differentiation. Lab Invest 1992;67: 42733.
  • 152
    Dailey L , Ambrosetti D , Mansukhani A , Basilico C . Mechanisms underlying differential responses to FGF signaling. Cytokine Growth Factor Rev 2005;16: 23347.
  • 153
    Hu Z , Evarts RP , Fujio K , Marsden ER , Thorgeirsson SS . Expression of fibroblast growth factor receptors flg and bek during hepatic ontogenesis and regeneration in the rat. Cell Growth Differ 1995;6: 101925.
  • 154
    Evarts RP , Hu Z , Fujio K , Marsden ER , Thorgeirsson SS . Activation of hepatic stem cell compartment in the rat: role of transforming growth factor α, hepatocyte growth factor, and acidic fibroblast growth factor in early proliferation. Cell Growth & Diff 1993;4: 55561.
  • 155
    Imai T , Masui T , Nakanishi H , Inada K , Kobayashi K , Nakamura T , Tatematsu M . Expression of hepatocyte growth factor and c-met mRNAs during rat chemically induced hepatocarcinogenesis. Carcinogenesis 1996;17: 1924.
  • 156
    Roselli HT , Su M , Washington K , Kerins DM , Vaughan DE , Russell WE . Liver regeneration is transiently impaired in urokinase-deficient mice. Am J Physiol 1998;275: G14729.
  • 157
    Odekon LE , Blasi F , Rifkin DB . Requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-β to TGF-β. J Cell Physiol 1994;158: 398407.
  • 158
    Bisgaard HC , Santoni-Rugiu E , Nagy P , Thorgeirsson SS . Modulation of the plasminogen activator/plasmin system in rat liver regenerating by recruitment of oval cells. Lab Invest 1998;78: 23746.
  • 159
    Matsusaka S , Tsujimua T , Toyosaka A , Nakasho K , Sugihara A , Okamoto E , Uematsu K , Terada N . Role of c-kit receptor tyrosine kinase in development of oval cells in the rat 2-acetylaminofluorene/partial hepatectomy model. Hepatology 1999;29: 6706.
  • 160
    Moussad EE , Brigstock DR . Connective tissue growth factor: what's in a name? Mol Genet Metab 2000;71: 27692.
  • 161
    Pi L , Oh S , Shupe T , Petersen BE . Role of connective tissue growth factor in oval cell response during liver regeneration after 2-AAF/PHx in rats. Gastroenterology 2005;128: 207788.
  • 162
    Schwall RH , Robbins K , Jardieu P , Chang L , Lai C , Terrell TG . Activin induces cell death in hepatocytes in vivo and in vitro. Hepatology 1993;18: 34756.
  • 163
    Braun L , Mead JE , Panzica M , Mikumo R , Bell GI , Fausto N . Transforming growth factor β mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation. Proc Natl Acad Sci USA 1988;85: 153943.
  • 164
    Schulte-Hermanm R , Bursch W , Low-Baselli A , Wagner A , Grasl-Kraupp B . Apoptosis in the liver and its role in hepatocarcinogenesis. Cell Biol Toxicol 1997;13: 33948.
  • 165
    Nakamura T , Ueno T , Sakamoto M , Sakata R , Torimura T , Hashimoto O , Ueno H , Sata M . Suppression of transforming growth factor-β results in upregulation of transcription of regeneration factors after chronic liver injury. J Hepatol 2004;41: 97482.
  • 166
    Romero-Gallo J , Sozmen EG , Chytil A , Russell WE , Whitehead R , Pars WT , Holdren MS , Her MF , Gautam S , Magnuson M , Moses HL , Grady WM . Inactivation of TGF-β signalling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene 2005;24: 302841.
  • 167
    Oe S , Lemmer ER , Conner EA , Factor VM , Leveen P , Larsson J , Karlsson S , Thorgeirsson SS . Intact signaling by transforming growth factor β is not required for termination of liver regeneration in mice. Hepatology 2004;40: 1098105.
  • 168
    Nagy P , Evarts RP , McMahon JB , Thorgeirsson SS . Role of TGF-β in normal differentiation and oncogenesis in rat liver. Mol Carcinog 1989;2: 34554.
  • 169
    Okamura H , Tsutsui H , Komatsu T , Yutsudo M , Hakura A , Tanimoto T , Torigoe K , Okura T , Nukada Y , Hattori K , Akita K , Namba M , Tanabe F , Konishi K , Fukuda S , Kurimoto M . Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 1995;378: 8891.
  • 170
    Kawakami K , Koguchi Y , Qureshi MH , Miyazato A , Yara S , Kinjo Y , Iwakura Y , Takeda K , Akira S , Kurimoto M , Saito A . IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-γ production by NK cells. J Immunol 2000;165: 9417.
  • 171
    Leite-de-Moraes MC , Hameg A , Arnould A , Machavoine F , Koezuka Y , Schneider E , Herbelin A , Dy M . A distinct IL-18-induced pathway to fully activate NK T lymphocytes independently from TCR engagement. J Immunol 1999;163: 58716.
  • 172
    Schroeder RA , Gu JS , Kuo PC . Interleukin 1β-stimulated production of nitric oxide in rat hepatocytes is mediated through endogenous synthesis of interferon-γ. Hepatology 1998;27: 7119.
  • 173
    Boehm U , Klamp T , Groot M , Howard JC . Cellular responses to interferon-γ. Annu Rev Immunol 1997;15: 74995.
  • 174
    Pestka S , Krause CD , Walter MR . Interferons, interferon-like cytokines, and their receptors. Immunol Rev 2004;202: 832.
  • 175
    Sato Y , Farges O , Buffello D , Bismuth H . Intra- and extrahepatic leukocytes and cytokine mRNA expression during liver regeneration after partial hepatectomy in rats. Dig Dis Sci 1999;44: 80616.
  • 176
    Akhurst B , Matthews V , Husk K , Smyth MJ , Abraham LJ , Yeoh GC . Differential lymphotoxin-β and interferon-γ signalling during mouse liver regeneration induced by chronic and acute injury. Hepatology 2005;41: 32735.
  • 177
    Sun R , Gao B . Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-γ). Gastroenterology 2004;127: 152539.
  • 178
    Sato Y , Tsukada K , Matsumoto Y , Abo T . Interferon-γ inhibits liver regeneration by stimulating major histocompatibility complex class II antigen expression by regenerating liver. Hepatology 1993;18: 3406.
  • 179
    Brooling JT , Campbell JS , Mitchell C , Yeoh GC , Fausto N . Differential regulation of rodent hepatocyte and oval cell proliferation by interferon γ. Hepatology 2005;41: 90615.
  • 180
    Bisgaard HC , Müller S , Nagy P , Rasmussen LJ , Thorgeirsson SS . Modulation of the gene network connected to interferon-γ in liver regeneration from oval cells. Am J Pathol 1999;155: 107585.
  • 181
    Braun KM , Thompson AW , Sandgren EP . Hepatic microenvironment affects oval cell localization in albumin-urokinase-type plasminogen activator transgenic mice. Am J Pathol 2003;162: 195202.
  • 182
    Knight B , Matthews VB , Akhurst B , Croager EJ , Klinken E , Abraham LJ , Olynk JK , Yeoh G . Liver inflammation and cytokine production, but not acute phase protein synthesis accompany the adult liver progenitor (oval) cell response to chronic liver injury. Immunol Cell Biol 2005;83: 36474.
    Direct Link:
  • 183
    March CJ , Mosley B , Larsen A , Cerretti DP , Braedt G , Price V , Gillis S , Henney CS , Kronheim SR , Grabstein K . Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 1985;315: 6417.
  • 184
    Carter DB , Deibel MR Jr , Dunn CJ , Tomich CS , Laborde AL , Slightom JL , Berger AE , Bienkowski MJ , Sun FF , McEwan RN . Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature 1990;344: 6338.
  • 185
    Howard AD , Kostura MJ , Thornberry N , Ding GJF , Limjuco G , Weidner J , Salley JP , Hogquist KA , Chaplin DD , Mumford RA , Schmidt JA , Tocci MJ . IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1β precursor at two distinct sites and does not cleave 31-kDa IL-1α. J Immunol 1991;147: 29649.
  • 186
    Dinarello CA . The IL-1 family and inflammatory diseases. Clin Exp Rheumatol 2002;20: S113.
  • 187
    Lee JK , Kim S-H , Lewis EC , Azam T , Reznikov LL , Dinarello CA . Differences in signalling pathways by IL-1β and IL-18. Proc Natl Acad Sci USA 2004;101: 881520.
  • 188
    Boulton R , Woodman A , Calnan D , Selden C , Tam F , Hodgson H . Nonparenchymal cells from regenerating rat liver generate interleukin-1α and -1β: a mechanism of negative regulation of hepatocyte proliferation. Hepatology 1997;26: 4958.
  • 189
    Boulton R , Alison MR , Golding M , Selden C , Hodgson HJ . Augmentation of the early phase of liver regeneration after 70% partial hepatectomy in rats following selective Kupffer cell depletion. J Hepatol 1998;29: 27180.
  • 190
    Tsutsumi M , Kamohara Y , Eguchi S , Azuma T , Fujioka H , Okudaira S , Yanafga K , Kanematsu T . Selective suppression of initial cytokine response facilitates liver regeneration after extensive hepatectomy in rats. Hepatogastroenterology 2004;51: 7014.
  • 191
    Subrata LS , Lowes KN , Olynyk JK , Yeoh GCT , Quail EA , Abraham LJ . Hepatic expression of the tumor necrosis factor family member lymphotoxin-β is regulated by interleukin (IL)-6 and IL-1β: transcriptional control mechanisms in oval cells and hepatoma cell lines. Liver Int 2005;25: 63346.
  • 192
    Schneider K , Potter KG , Ware CF . Lymphotoxin and LIGHT signaling pathways and target genes. Immunol Rev 2004;202: 4966.
  • 193
    Browning JL , Dougas I , Ngam-ek A , Bourdon PR , Ehrenfels BN , Miatkowski K , Zafari M , Yampaglia AM , Lawton P , Meier W , Benjamin CP , Hession C . Characterization of surface lymphotoxin forms. J Immunol 1995;154: 3346.
  • 194
    Abe K , Yarovinsky FO , Murakami T , Shakhov AN , Tumanov AV , Ito D , Drutskaya LN , Pfeffer K , Kuprash DV , Komschlies KL , Nedospasov SA . Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo. Blood 2003;101: 147783.
  • 195
    Kabashima K , Banks TA , Ansel KM , Lu TT , Ware CF , Cyster JG . Intrinsic lymphotoxin-β receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity 2005;22: 43950.
  • 196
    Knight B , Yeoh GC . TNF/LTα double knockout mice display abnormal inflammatory and regenerative responses to acute and chronic liver injury. Cell Tissue Res 2005;319: 6170.
  • 197
    Lee CM , Knight B , Yeoh GC , Ramn GA , Olynk JK . Lymphotoxin-β production following bile duct ligation: possible role for Kupffer cells. J Gastroenterol Hepatol 2005;20: 17628.
  • 198
    Lowes KN , Croager EJ , Abraham LJ , Olynyk JK , Yeoh GC . Upregulation of lymphotoxin β expression in liver progenitor (oval) cells in chronic hepatitis C. Gut 2003;52: 132732.
  • 199
    Ajuebor MN , Swain MG . Role of chemokines and chemokine receptors in the gastrointestinal tract. Immunology 2002;105: 13743.
  • 200
    Rosenkilde MM , Schwartz TW . The chemokine system – a major regulator of angiogenesis in health and disease. APMIS 2004;112: 48195.
  • 201
    Esche C , Stellato C , Beck LA . Chemokines: key players in innate and adaptive immunity. J Invest Dermatol 2005;125: 61528.
  • 202
    Broxmeyer HE , Kim CH , Cooper SH , Hangoc G , Hromas R , Pelus LM . Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors. Ann NY Acad Sci 1999;872: 14262.
  • 203
    Colletti LM , Green M , Burdick MD , Kunkel SL , Strieter RM . Proliferative effects of CXC chemokines in rat hepatocytes in vitro and in vivo. Shock 1998;10: 24857.
  • 204
    Ren X , Carpenter A , Hogaboam C , Colletti L . Mitogenic properties of endogenous and pharmacological doses of macrophage inflammatory protein-2 after 70% hepatectomy in the mouse. Am J Pathol 2003;163: 56370.
  • 205
    Hogaboam CM , Bone-Larson CL , Steinhauser ML , Lukacs NW , Colletti LM , Simpson KJ , Strieter RM , Kunkel SL . Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines. FASEB J 1999;13: 156574.
  • 206
    Ren X , Kennedy A , Colletti LM . CXC chemokine expression after stimulation with interferon-γ in primary rat hepatocytes in culture. Shock 2002;17: 51320.
  • 207
    Murdoch C . CXCR4: chemokine receptor extraordinaire. Immunol Rev 2000;177: 17584.
  • 208
    Ma Q , Jones D , Borghesani PR , Segal RA , Nagasawa T , Kishimoto T , Bronson RT , Springer RA . Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci USA 1998;95: 944853.
  • 209
    Coulomb-L'Hermin A , Amara A , Schiff C , Durand-Gasselin I , Foussat A , Delaunay T , Chaouat G , Capron F , Ledee N , Galanaud P , Arenzana-Seisdedos F , Emilie D . Stromal cell-derived factor 1 (SDF-1) and antenatal human B cell lymphopoiesis: expression of SDF-1 by mesothelial cells and biliary ductal plate epithelial cells. Proc Natl Acad Sci USA 1999;96: 858590.
  • 210
    Jordan NJ , Kolios G , Abbot SE , Sinai MA , Thompson DA , Petraki K , Westwick J . Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. J Clin Invest 1999;104: 10619.
  • 211
    Kayali AG , Van Gunst K , Campbell IL , Stotland A , Kritzik M , Liu G , Flodström-Tullberg M , Zhang Y , Sarvetnick N . The stromal cell-derived factor-1α/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. J Cell Biol 2003;163: 85969.