Received 7 June 2007.
In vivo prion protein intestinal uptake in fish†
Version of Record online: 29 MAR 2008
Volume 116, Issue 3, pages 173–180, March 2008
How to Cite
DALLA VALLE, A. Z., IRITI, M., FAORO, F., BERTI, C. and CIAPPELLANO, S. (2008), In vivo prion protein intestinal uptake in fish. APMIS, 116: 173–180. doi: 10.1111/j.1600-0463.2008.00863.x
Accepted 4 September 2007.
- Issue online: 29 MAR 2008
- Version of Record online: 29 MAR 2008
- Prion protein;
- rainbow trout;
- intestinal uptake;
- animal nutrition;
Intestinal uptake of abnormal prion protein (PrPSc), the pathological agent involved in transmissible spongiform encephalopathies (TSEs), has been investigated in rainbow trout (Oncorhynchus mykiss). Experimental procedures were conducted in vivo by immunohistological PrPSc localization in intestine and pyloric caeca after forced feeding of infected material. Results indicate that PrPSc was absorbed by the intestinal mucosa and that it persisted in the fish gastrointestinal tract for up to 3 days in pyloric caeca and for up to 7 days in the distal intestine. It did not remain longer than 15 days in the fish intestine; furthermore, it did not cross the intestinal barrier.