Epitope-specific anti-neutrophil cytoplasmic antibodies: Do they matter? Can they be detected?
Article first published online: 1 JUN 2009
© 2009 The Author. Journal Compilation © 2009 APMIS
Special Issue: Proceedings of the 14th International Vasculitis and ANCA Workshop
Volume 117, Issue Supplement s127, pages 63–66, June 2009
How to Cite
SPECKS, U. (2009), Epitope-specific anti-neutrophil cytoplasmic antibodies: Do they matter? Can they be detected?. APMIS, 117: 63–66. doi: 10.1111/j.1600-0463.2009.02503.x
- Issue published online: 1 JUN 2009
- Article first published online: 1 JUN 2009
- Invited Review
- epitope specificity;
- conformational epitopes;
- monoclonal antibodies;
- chimeric molecules
Proteinase 3 (PR3)-anti-neutrophil cytoplasmic antibodies (ANCA) and myeloperoxidase (MPO)-ANCA are suggested to play a pathogenic role as they are closely related to the small-vessel vasculitis syndromes, Wegener's granulomatosis and microscopic polyangiitis. A large body of in vitro and animal experiments supports this concept. The mechanisms of action involve a direct interaction between ANCA and its antigen. The epitope specificity of ANCA may therefore influence the functional effects of ANCA and/or may reflect the mechanisms behind different disease manifestations or disease courses.