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Bone formation after sinus augmentation with engineered bone


Correspondence to:
Dr Christoph Zizelmann
Clinic and Policlinic for Oral and Maxillofacial Surgery
University Hospital Freiburg
Hugstetter Strasse 55
D-79106 Freiburg
Tel.: +49 761 2704819
Fax: +49 761 2704800


Objectives: The aim of the following investigation was to quantify the resorption rate of tissue-engineered bone grafts in the maxillary sinus using volume measurements.

Material and methods: Sinus floor augmentation using autologous bone grafts from the iliac crest (n=17, group 1) was compared with commercially produced transplants of human cells seeded on polyglycolid–polylactid (PLGA) scaffolds (Oral Bone®) (n=14, group 2).

Results: The total resorption rate for autologous transplants 3 months post operation was 29%, while the tissue-engineered bone showed a resorption rate of 90%.

The autologous bone had a bone density of up to 266–551 Hounsfield units (HU), while sufficient mineralization of tissue-engineered bone was found in only one case (152 HU).

Conclusion: In this clinical study, the use of autologous cancellous bone grafts in sinus augmentation was more reliable than scaffolds containing cultured osteoblasts. Further tissue-engineered bone transplants should be examined to draw general conclusions about the use of tissue-engineered grafts compared with autologous bone grafts for maxillary sinus augmentation.