Evaluation of functional dynamics during osseointegration and regeneration associated with oral implants
Article first published online: 15 DEC 2009
© 2009 John Wiley & Sons A/S
Clinical Oral Implants Research
Volume 21, Issue 1, pages 1–12, January 2010
How to Cite
Chang, P.-C., Lang, N. P. and Giannobile, W. V. (2010), Evaluation of functional dynamics during osseointegration and regeneration associated with oral implants. Clinical Oral Implants Research, 21: 1–12. doi: 10.1111/j.1600-0501.2009.01826.x
- Issue published online: 15 DEC 2009
- Article first published online: 15 DEC 2009
- Date: Accepted 16 July 2009
- bone–implant interactions;
- finite element analysis;
- growth factor
Objectives: The aim of this paper is to review current investigations on functional assessments of osseointegration and assess correlations to the peri-implant structure.
Material and methods: The literature was electronically searched for studies of promoting dental implant osseointegration, functional assessments of implant stability, and finite element (FE) analyses in the field of implant dentistry, and any references regarding biological events during osseointegration were also cited as background information.
Results: Osseointegration involves a cascade of protein and cell apposition, vascular invasion, de novo bone formation and maturation to achieve the primary and secondary dental implant stability. This process may be accelerated by alteration of the implant surface roughness, developing a biomimetric interface, or local delivery of growth-promoting factors. The current available pre-clinical and clinical biomechanical assessments demonstrated a variety of correlations to the peri-implant structural parameters, and functionally integrated peri-implant structure through FE optimization can offer strong correlation to the interfacial biomechanics.
Conclusions: The progression of osseointegration may be accelerated by alteration of the implant interface as well as growth factor applications, and functional integration of peri-implant structure may be feasible to predict the implant function during osseointegration. More research in this field is still needed.
To cite this article: Chang P-C, Lang NP, Giannobile WV. Evaluation of functional dynamics during osseointegration and regeneration associated with oral implants. Clin. Oral Impl. Res. 21, 2010; 1–12.