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Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized clinical trial

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Errata

This article is corrected by:

  1. Errata: Corrigendum Volume 22, Issue 7, 777, Article first published online: 12 June 2011

Correspondence to:
Arjan Vissink
Department of Oral & Maxillofacial Surgery
University Medical Center
PO Box 30.001
9700 RB Groningen
the Netherlands
Tel.:+31 50 3613840
Fax.:+31 50 3611161
e-mail: a.vissink@kchir.umcg.nl

Abstract

Aim: To assess whether differences occur in bone formation after maxillary sinus floor elevation surgery with bovine bone mineral (BioOss®) mixed with autogenous bone or autogenous stem cells. The primary endpoint was the percentage of new bone three months after the elevation procedure.

Material and methods: In a randomized, controlled split-mouth design, in 12 consecutive patients (age 60.8 ± 5.9 years, range 48–69 years) needing reconstruction of their atrophic maxilla, a bilateral sinus floor augmentation procedure was performed. Randomly, on one side the augmentation procedure was performed with bovine bone mineral (BioOss®) seeded with mononuclear stem cells harvested from the posterior iliac crest (test group) while BioOss® mixed with autogenous bone (harvested from the retromolar area) was applied on the contra-lateral side (control group). On 14.8 ± 0.7 weeks after the sinus floor elevation, biopsies from the reconstructed areas were taken at the spots where subsequently the endosseous implants were placed. The biopsies were histomorphometrically analyzed.

Results: Significantly more bone formation was observed in the test group (17.7 ± 7.3%) when compared with the control group (12.0%± 6.6; P=0.026). In both the test and control group, all implants could be placed with primary stability. In one patient, not all biopsies contained BioOss®. This patient was excluded from analysis.

Conclusion: Mesenchymal stem cells seeded on BioOss® particles can induce the formation of a sufficient volume of new bone to enable the reliable placement of implants within a time frame comparable with that of applying either solely autogenous bone or a mixture of autogenous bone and BioOss®. This technique could be an alternative to using autografts.

To cite this article: Rickert D, Sauerbier S, Nagursky H, Menne D, Vissink A, Raghoebar GM. Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized clinical trial.
Clin. Oral Impl. Res. 22, 2011; 251–258.
doi: 10.1111/j.1600-0501.2010.01981.x

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