Evaluation of the osteoconductive potential of bone substitutes embedded with schneiderian membrane- or maxillary bone marrow-derived osteoprogenitor cells
Article first published online: 6 AUG 2012
© 2012 John Wiley & Sons A/S
Clinical Oral Implants Research
Volume 24, Issue 12, pages 1288–1294, December 2013
How to Cite
Evaluation of the osteoconductive potential of bone substitutes embedded with Schneiderian membrane- or maxillary bone marrow-derived osteoprogenitor cellsClin. Oral Impl. Res. 24, 2013, 1288–1294, , , , .
- Issue published online: 27 OCT 2013
- Article first published online: 6 AUG 2012
- Manuscript Accepted: 29 JUN 2012
- EU Genostem. Grant Number: 2003522
- sinus augmentation
Sinus augmentation procedures commonly employ osteoconductive scaffolding materials to stimulate and support bone formation. The aim of this study was to develop a simple screening methodology for the evaluation of the osteoconductive potential of various bone graft materials prior to clinical use.
Materials and methods
Materials tested were Bio-Oss, Bi-Ostetic, OraGraft, and ProOsteon. These Simple and composite bone substitutes were embedded with osteoprogenitor cells derived from either the human maxillary sinus schneiderian membrane (hMSSM) or from maxillary tuberosity bone marrow and then monitored both in vitro and in vivo.
Cell adherence and proliferation was most pronounced in OraGraft, followed by ProOsteon. In vivo bone formation, within the bone graft, was also observed, with most marked results in OraGraft and ProOsteon grafts.
The proposed osteoconductivity testing method proved simple, informative, and reliable for the purpose of screening candidate biomaterials for sinus lifting or sinus augmentation.