Dynamics of infection by leukotoxic strains of actinobacillus actinomycetemcomitans in juvenile periodontitis

Authors

  • Chi-Cheng Tsai,

    1. University of Pennsylvania, School of Dental Medicine, Department of Pathology, Philadelphia, PA 19104, USA
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      Kaoshiung Medical Coilege, Kaoshiung, Repubiic of China.

  • Norton S. Taichman

    Corresponding author
    1. University of Pennsylvania, School of Dental Medicine, Department of Pathology, Philadelphia, PA 19104, USA
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Dr. N. S. Taichman, University of Pennsylvania School of Dental Medicine Department of Pathology Philadelphia, PA 19104 USA

Abstract

Abstract. Juvenile periodontitis is associated with a high incidence of infection by Actinobacillus aclinomycetemcomilans (Aa). The data presented indicate that the ability of Aa to destroy human PMNs is altered during the course of infection. Leukotoxic strains of Aa are characteristically found in isolates obtained from younger patients (6–12 years of age) but not in older subjects (13–25 years old). This suggests that the leukotoxin may be more important during early as opposed to more advanced phases of juvenile periodontitis.

Ancillary