Robin Davies and Roger Ellwood are employees of Colgate Ltd, UK.
The effectiveness of a toothpaste containing Triclosan and polyvinyl-methyl ether maleic acid copolymer in improving plaque control and gingival health
A systematic review
Article first published online: 19 NOV 2004
Journal of Clinical Periodontology
Volume 31, Issue 12, pages 1029–1033, December 2004
How to Cite
Davies, R. M., Ellwood, R. P. and Davies, G. M. (2004), The effectiveness of a toothpaste containing Triclosan and polyvinyl-methyl ether maleic acid copolymer in improving plaque control and gingival health. Journal of Clinical Periodontology, 31: 1029–1033. doi: 10.1111/j.1600-051X.2004.00614.x
- Issue published online: 19 NOV 2004
- Article first published online: 19 NOV 2004
- Accepted for publication 15 March 2004
- systematic review;
- triclosan/copolymer toothpaste
Objective: To compare the effectiveness of triclosan/copolymer and fluoride dentifrices in improving plaque control and gingival health.
Search strategy: We searched the Cochrane Controlled Trials Register, MEDLINE (1986 to March 2003) and EMBASE (1986 to March 2003). Personal files and the reference lists of all articles were checked for further studies.
Selection criteria: Trials were selected if they met the following criteria: random allocation of participants; participants were adults with plaque and gingivitis; unsupervised use of dentifrices for at least 6 months; and primary outcomes – plaque and gingivitis after 6 months.
Data collection and analysis: Two reviewers independently extracted information. For each plaque and gingivitis index, the mean differences for each study were pooled as weighted mean differences (WMDs) with the appropriate 95% confidence intervals (CIs) using the random effect models.
Main results: Sixteen trials provided data for the meta-analysis. The triclosan/copolymer dentifrice significantly improved plaque control compared with a fluoride dentifrice, with a WMD of −0.48 (95% CI: −0.64 to −0.32) for the Quigley–Hein index and WMD of −0.15 (95% CI: −0.20 to −0.09) for the plaque severity index. When compared with a fluoride dentifrice, the triclosan/copolymer dentifrice significantly reduced gingivitis with WMDs −0.26 (95% CI: −0.34 to −0.18) and −0.12 (95% CI: −0.17 to −0.08) for the Loe and Silness index and gingivitis severity index, respectively.