Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration

  1. Anton Sculean1,
  2. Alice Kiss2,
  3. Asta Miliauskaite2,
  4. Frank Schwarz3,
  5. Nicole B. Arweiler4,
  6. Matthias Hannig2

Article first published online: 21 JUL 2008

DOI: 10.1111/j.1600-051X.2008.01295.x

Issue

Journal of Clinical Periodontology

Journal of Clinical Periodontology

Volume 35, Issue 9, pages 817–824, September 2008

Additional Information

How to Cite

Sculean, A., Kiss, A., Miliauskaite, A., Schwarz, F., Arweiler, N. B. and Hannig, M. (2008), Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration. Journal of Clinical Periodontology, 35: 817–824. doi: 10.1111/j.1600-051X.2008.01295.x

Author Information

  1. 1

    Department of Periodontology, Radboud University Medical Center, Nijmegen, The Netherlands

  2. 2

    Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, University of Saarland, Homburg, Germany

  3. 3

    Department of Oral Surgery, Heinrich Heine University, Düsseldorf, Germany

  4. 4

    Department of Operative Dentistry and Periodontology, Albert-Ludwigs-University, Freiburg, Germany

*Address: Anton Sculean Department of Periodontology Radboud University Medical Center P.O. Box 9101, Internal Postal Code 117 6500 Nijmegen, Philips van Leydenlaan 25 The Netherlands E-mail: anton.sculean@gmx.de

Publication History

  1. Issue published online: 13 AUG 2008
  2. Article first published online: 21 JUL 2008
  3. Accepted for publication 9 June 2008

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (160K)

Keywords:

  • bioresorbable membranes;
  • enamel matrix protein derivative;
  • guided tissue regeneration;
  • long-term results;
  • regenerative periodontal therapy

Abstract

Background: Surgery utilizing an enamel matrix protein derivative (EMD) or guided tissue regeneration (GTR) has been shown to promote periodontal regeneration.

Aim: To evaluate the 10-year results following treatment with EMD, GTR, EMD+GTR, and open flap debridement (OFD).

Material and Methods: Thirty-eight patients out of an initial group of 56 participants were treated with one of the four modalities. Results were evaluated before surgery, at 1 year, and at 10 years. Primary outcome variable was CAL change.

Results: Treatment with EMD yielded a mean CAL gain of 3.4±1.0 mm (p<0.001) and 2.9±1.4 mm (p<0.001) at 1 and 10 years, respectively. GTR resulted in a mean CAL gain of 3.2±1.4 (p<0.001) at 1 year and 2.8±1.2 mm (p<0.001) at 10 years. Mean CAL gain in the EMD+GTR group was of 3.3±1.1 mm (p<0.001) and 2.9±1.2 mm (p<0.001) at 1 and 10 years, respectively. Treatment with OFD demonstrated a mean CAL gain of 2.0±1.2 mm (p<0.01) at 1 year and 1.8±1.1 mm (p<0.01) at 10 years. Compared with OFD, the three regenerative treatments resulted in statistically significant (p<0.05) higher CAL gain, at both 1 and 10 years. The CAL change between 1 and 10 years did not present statistically significant differences in any of the four groups.

Conclusion: The present results indicate that the clinical outcomes obtained with all four approaches can be maintained over a period of 10 years.

View Full Article (HTML) Get PDF (160K)