Conflict of interest and source of funding statement The authors declare that they have no conflicts of interests. This work was supported by a research and technological development project grant from the European Commission FP5 “Quality of Life and Management of Living Resources” (QLK6-2002-02243).
Tooth loss and osteoporosis: the osteodent study
Article first published online: 10 FEB 2009
© 2009 John Wiley & Sons A/S
Journal of Clinical Periodontology
Volume 36, Issue 3, pages 190–197, March 2009
How to Cite
Nicopoulou-Karayianni, K., Tzoutzoukos, P., Mitsea, A., Karayiannis, A., Tsiklakis, K., Jacobs, R., Lindh, C., Van Der Stelt, P., Allen, P., Graham, J., Horner, K., Devlin, H., Pavitt, S. and Yuan, J. (2009), Tooth loss and osteoporosis: the osteodent study. Journal of Clinical Periodontology, 36: 190–197. doi: 10.1111/j.1600-051X.2008.01365.x
- Issue published online: 10 FEB 2009
- Article first published online: 10 FEB 2009
- Accepted for publication 17 November 2008.
- bone mineral density;
- tooth loss
Aim: To determine the cross-sectional association of the osteoporotic status of patients with the number of their teeth, with and without taking into account age and/or smoking.
Material & Methods: At four centres, the study recruited 665 females aged 45–70 years and the number of teeth was counted for 651 subjects. Bone density was measured at the total hip, femoral neck and lumbar spine.
Results: The mean number of teeth in the osteoporotic subjects was 3.3 fewer than normal subjects and 2.1 fewer if those with no teeth were excluded. The association between osteoporosis and having <6 or having <28 teeth remained significant after adjusting for age, smoking and centre with p-values of 0.016 and 0.011, respectively. A single regression model for tooth count with normal errors would not fit all the data. By fitting mixture regression models to subjects with tooth count >0, three clusters were identified corresponding to different degrees of tooth loss. The overall effect of osteoporosis was as follows: −1.8 teeth before and after adjusting for smoking, −1.2 teeth after adjusting for age, and −1.1 teeth after adjusting for both age and smoking.
Conclusions: We have established a significant association between osteoporosis and tooth loss after adjusting the effect for age and smoking.