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Journal of Clinical Periodontology

Physical activity, inflammatory biomarkers in gingival crevicular fluid and periodontitis

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  • Conflict of interest and sources of funding statements
    The authors declare that they have no conflict of interests.
    The National Survey of Adult Oral Health was supported by National Health and Medical Research Council (NHMRC) Project Grants No 299060 and 349514; Australian Government Department of Health and Ageing, Population Health Division; Australian Institute of Health and Welfare; Colgate Oral Care; Australian Dental Association; and US Centers for Disease Control and Prevention's Research Participation Program. Dr. Anne Sanders is supported by an NHMRC Sidney Sax (Public Health) Fellowship.

Address:
Anne E. Sanders
Australian Research Centre for Population Oral Health
School of Dentistry
The University of Adelaide
Adelaide
Australia 5005
E-mail: anne.sanders@adelaide.edu.au

Abstract

Aims: To examine the associations of physical activity with interleukin 1-β (IL-1β), C-reactive protein (CRP) and periodontitis and to investigate whether any relationship between physical activity and inflammatory mediators differs between periodontitis cases and non-cases.

Material and Methods: In this population-based case control study of Australians aged 18+ years, dentists conducted oral epidemiologic examinations identifying cases with moderate or severe periodontitis and periodontally healthy controls. Gingival crevicular fluid samples collected during examinations were analysed for inflammatory biomarkers. Subject-completed questionnaires assessed leisure-time physical activity. Exposure odds ratios (ORs) were estimated in multivariable logistic regression models adjusting for periodontitis risk indicators.

Results: Of 751 subjects (359 cases, 392 controls), those meeting a prescribed threshold for leisure-time physical activity had lower adjusted odds of elevated IL-1β: OR=0.69, (95% CI=0.50–0.94) and detectable CRP: OR=0.70 (0.50–0.98) than less active adults. Physical activity was not associated with periodontitis: OR=1.14 (0.80–1.62). Periodontitis modified the association between levels of physical activity and detectable CRP. Increasing quartiles of physically activity were associated with decreasing probability of detectable CRP, but the effect was limited to periodontitis cases and was not apparent among non-cases.

Conclusion: Leisure-time physical activity may protect against an excessive inflammatory response in periodontitis.

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