The influence of a probiotic milk drink on the development of gingivitis: a pilot study

  1. Benedict Staab1,
  2. Sigrun Eick2,
  3. Gerhild Knöfler1,
  4. Holger Jentsch1

Article first published online: 12 AUG 2009

DOI: 10.1111/j.1600-051X.2009.01459.x

Issue

Journal of Clinical Periodontology

Journal of Clinical Periodontology

Volume 36, Issue 10, pages 850–856, October 2009

Additional Information

How to Cite

Staab, B., Eick, S., Knöfler, G. and Jentsch, H. (2009), The influence of a probiotic milk drink on the development of gingivitis: a pilot study. Journal of Clinical Periodontology, 36: 850–856. doi: 10.1111/j.1600-051X.2009.01459.x

Author Information

  1. 1

    Department of Conservative Dentistry and Periodontology, Medical Faculty, University of Leipzig, Leipzig, Germany

  2. 2

    Institute of Medical Microbiology, University Hospital Jena, Jena, Germany

*Address: Holger Jentsch Department of Conservative Dentistry and Periodontology Medical Faculty University of Leipzig Nürnberger Str. 57 D-04103 Leipzig Germany E-mail: jenh@medizin.uni-leipzig.de

Publication History

  1. Issue published online: 10 SEP 2009
  2. Article first published online: 12 AUG 2009
  3. Accepted for publication 22 June 2009

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Keywords:

  • gingival crevicular fluid;
  • gingivitis;
  • probiotics

Abstract

Aim: The aim of this study was to determine the effect of a probiotic milk drink on gingival health and the development of experimental gingivitis.

Material and Methods: Fifty volunteer students took part in a parallel-designed non-blinded study. The test group drank a probiotic drink once a day; the control group did not receive any product to drink. After 8 weeks, individual mechanical plaque control was interrupted for 96 h. Papilla bleeding index, interproximal plaque and Turesky plaque index (PI) were recorded at baseline, after 8 weeks and again 96 h later. At the same time points, gingival crevicular fluid had been collected for analysis of polymorphonuclear elastase, myeloperoxidase (MPO) and matrix metalloproteinase-3 (MMP-3).

Results: Interproximal PI and papillary bleeding were not different between the groups. In the test group, elastase activity and MMP-3 amount were significantly lower after the intake of the probiotic milk drink (p<0.001 and 0.016). There was a significant increase of MPO activity in the control group; both groups were different at the end of the study (p=0.014).

Conclusions: The data suggest a beneficial effect of the probiotic milk drink on gingival inflammation.

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