Conflict of interest and source of funding statement The authors report no conflicts of interest related to this study. No financial support was received.
Evidence grade associating periodontitis with preterm birth and/or low birth weight: II. A systematic review of randomized trials evaluating the effects of periodontal treatment
Article first published online: 7 JUL 2011
© 2011 John Wiley & Sons A/S
Journal of Clinical Periodontology
Volume 38, Issue 10, pages 902–914, October 2011
How to Cite
Chambrone, L., Pannuti, C. M., Guglielmetti, M. R. and Chambrone, L. A. (2011), Evidence grade associating periodontitis with preterm birth and/or low birth weight: II. A systematic review of randomized trials evaluating the effects of periodontal treatment. Journal of Clinical Periodontology, 38: 902–914. doi: 10.1111/j.1600-051X.2011.01761.x
- Issue published online: 12 SEP 2011
- Article first published online: 7 JUL 2011
- Accepted for publication 5 June 2011
- low birth weight;
- periodontal diseases;
- premature birth;
- systematic review;
Chambrone L, Pannuti CM, Guglielmetti MR, Chambrone LA. Evidence grade associating periodontitis with preterm birth and/or low birth weight. II. A systematic review of randomized trials evaluating the effects of periodontal treatment. J Clin Periodontol 2011; 38: 902–914. doi: 10.1111/j.1600-051X.2011.01761.x.
Aim: The aim of this systematic review was to evaluate whether maternal periodontal disease treatment (MPDT) can reduce the incidence of preterm birth (PB) and/or low birth weight (LBW).
Methods: The Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE were searched for entries up to October 2010 without restrictions regarding the language of publication. Only randomized-controlled clinical trials (RCTs) that evaluated the effect of MPDT on birth term and birth weight were included. The search was conducted by two independent reviewers and random-effects meta-analyses were conducted methodically.
Results: Thirteen RCTs provided data, but only five trials were considered to be at a low risk of bias. The results of eight studies (61.5%) showed that MPDT may reduce the incidence of PB and/or LBW. However, the results of all meta-analyses showed contrasting results for PB [RR: 0.88 (95% CI: 0.72, 1.09)], LBW [RR: 0.78 (95% CI: 0.53, 1.17)] and PB/LBW [RR: 0.52 (95% CI: 0.08, 3.31)].
Conclusion: The results of this review show that MPDT did not decrease the risk of PB and/or LBW; however, the influence of specific aspects that were not investigated (disease diagnosis, extension and severity and the success of MPDT) should be evaluated by future RCTs.