Get access
Journal of Clinical Periodontology

Evidence grade associating periodontitis with preterm birth and/or low birth weight: II. A systematic review of randomized trials evaluating the effects of periodontal treatment

Authors


  • Conflict of interest and source of funding statement
    The authors report no conflicts of interest related to this study.
    No financial support was received.

Address:
Leandro Chambrone
Disciplina de Periodontia
Departamento de Estomatologia
Faculdade de Odontologia
Universidade de Sao Paulo
Av. Prof. Lineu Prestes
2227 Cidade Universitaria
05508-000 Sao Paulo, SP
Brazil
E-mail: chambrone@usp.br

Abstract

Chambrone L, Pannuti CM, Guglielmetti MR, Chambrone LA. Evidence grade associating periodontitis with preterm birth and/or low birth weight. II. A systematic review of randomized trials evaluating the effects of periodontal treatment. J Clin Periodontol 2011; 38: 902–914. doi: 10.1111/j.1600-051X.2011.01761.x.

Abstract

Aim: The aim of this systematic review was to evaluate whether maternal periodontal disease treatment (MPDT) can reduce the incidence of preterm birth (PB) and/or low birth weight (LBW).

Methods: The Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE were searched for entries up to October 2010 without restrictions regarding the language of publication. Only randomized-controlled clinical trials (RCTs) that evaluated the effect of MPDT on birth term and birth weight were included. The search was conducted by two independent reviewers and random-effects meta-analyses were conducted methodically.

Results: Thirteen RCTs provided data, but only five trials were considered to be at a low risk of bias. The results of eight studies (61.5%) showed that MPDT may reduce the incidence of PB and/or LBW. However, the results of all meta-analyses showed contrasting results for PB [RR: 0.88 (95% CI: 0.72, 1.09)], LBW [RR: 0.78 (95% CI: 0.53, 1.17)] and PB/LBW [RR: 0.52 (95% CI: 0.08, 3.31)].

Conclusion: The results of this review show that MPDT did not decrease the risk of PB and/or LBW; however, the influence of specific aspects that were not investigated (disease diagnosis, extension and severity and the success of MPDT) should be evaluated by future RCTs.

Get access to the full text of this article

Ancillary