The association of Aggregatibacter actinomycetemcomitans with preeclampsia in a subset of Japanese pregnant women

Authors

  • Emi Hirano,

    1. Division of Periodontology, Department of Oral Biological Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
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  • Noriko Sugita,

    Corresponding author
    • Division of Periodontology, Department of Oral Biological Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
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  • Akira Kikuchi,

    1. Department of Obstetrics and Gynecology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
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  • Yasuko Shimada,

    1. Division of Periodontology, Department of Oral Biological Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
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  • Jun Sasahara,

    1. Department of Obstetrics and Gynecology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
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  • Ruriko Iwanaga,

    1. Division of Periodontology, Department of Oral Biological Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
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  • Kenichi Tanaka,

    1. Department of Obstetrics and Gynecology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
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  • Hiromasa Yoshie

    1. Division of Periodontology, Department of Oral Biological Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
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  • Conflict of interest and sources of funding statement

    The authors report no conflict of interest related to this study.

    This work was supported by Grants-in-Aid for Scientific Research (19592385) and for Challenging Exploratory Research (21659480) from Japan Society for the Promotion of Science (JSPS), Tokyo, Japan.

Address:

N. Sugita

Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, Japan

E-mail: psugita@dent.niigata-u.ac.jp

Abstract

Aim

To determine whether periodontitis and three prominent members of the periodontal flora are associated with the development of preeclampsia (hypertension plus proteinuria)

Materials and Methods

The samples were composed of 127 systemically healthy women. Within 5 days after labour, clinical periodontal parameters and Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia in subgingival plaque were evaluated. Maternal serum IgG antibody specific for each bacteria was determined by enzyme-linked immunosorbent assay. Multivariate logistic regression analysis was used to control for confounders (maternal age, body mass index before pregnancy, parity, and smoking).

Results

Eighteen women were affected with preeclampsia. The number of A.actinomycetemcomitans was shown to be significantly associated with preeclampsia in the logistic regression model (odds ratio; 1.7, 95% confidence interval; 1.1–2.7). There were statistically significant differences between the preeclamptic and control groups in body mass index before pregnancy, pre-term birth and low birthweight (respectively, = 0.014, = 0.010 and < 0.0001). We found no statistically significant association between preeclampsia and periodontal clinical parameters or the presence of periodontitis.

Conclusion

In systemically healthy pregnant women, our findings suggested that the levels of maternal subgingival A. actinomycetemcomitans DNA were elevated in preeclamptic women.

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