All-cause mortality and periodontitis in 60–70-year-old men: a prospective cohort study

Authors

  • Gerard J. Linden,

    Corresponding author
    • Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, UK
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  • Katie Linden,

    1. Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, UK
    2. School of Medicine, University of Dundee, Dundee, Scotland, UK
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  • John Yarnell,

    1. Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, UK
    2. UKCRC Centre of Excellence for Public Health (NI), Queen's University Belfast, Belfast, Northern Ireland, UK
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  • Alun Evans,

    1. Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, UK
    2. UKCRC Centre of Excellence for Public Health (NI), Queen's University Belfast, Belfast, Northern Ireland, UK
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  • Frank Kee,

    1. Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, UK
    2. UKCRC Centre of Excellence for Public Health (NI), Queen's University Belfast, Belfast, Northern Ireland, UK
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  • Chris C. Patterson

    1. Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, UK
    2. UKCRC Centre of Excellence for Public Health (NI), Queen's University Belfast, Belfast, Northern Ireland, UK
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  • Conflict of interest and source of funding statement

  • The authors have no conflict of interests in relation to this research study.

  • This research was supported by a grant from the Northern Ireland NHS Research and Development Fund.

Address:

Gerry Linden

Periodontal Department

School of Dentistry

Queen's University

Grosvenor Road, Belfast

Northern Ireland, BT12 6BP

UK

E-mail: g.linden@qub.ac.uk

Abstract

Objective

To investigate the association between periodontitis and mortality from all causes in a prospective study in a homogenous group of 60- to 70-year-old West European men.

Methodology

A representative sample of 1400 dentate men, (mean age 63.8, SD 3.0 years), drawn from the population of Northern Ireland, had a comprehensive periodontal examination between 2001 and 2003. Men were divided into thirds on the basis of their mean periodontal attachment loss (PAL). The primary endpoint, death from any cause, was analysed using Kaplan–Meier survival plots and Cox's proportional hazards model.

Results

In total, 152 (10.9%) of the men died during a mean follow-up of 8.9 (SD 0.7) years; 37 (7.9%) men in the third with the lowest PAL (<1.8 mm) died compared with 73 (15.7%) in the third with the highest PAL (>2.6 mm). The unadjusted hazard ratio (HR) for death in the men with the highest level of PAL compared with those with the lowest PAL was 2.11 (95% CI 1.42–3.14), < 0.0001. After adjustment for confounding variables (age, smoking, hypertension, BMI, diabetes, cholesterol, education, marital status and previous history of a cardiovascular event) the HR was 1.57 (1.04–2.36), = 0.03.

Conclusion

The European men in this prospective cohort study with the most severe loss of periodontal attachment were at an increased risk of death compared with those with the lowest loss of periodontal attachment.

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