Conflict of interests and source of funding statement
Association between the insulin-like growth factor axis in serum and periodontitis in the Study of Health in Pomerania: an exploratory study
Article first published online: 9 AUG 2012
© 2012 John Wiley & Sons A/S
Journal of Clinical Periodontology
Volume 39, Issue 10, pages 931–939, October 2012
How to Cite
Association between the insulin-like growth factor axis in serum and periodontitis in the Study of Health in Pomerania: an exploratory study. J Clin Periodontol 2012; doi: 10.1111/j.1600-051X.2012.01935.x., , , , , , , , .
SHIP is part of the Community Medicine Research net (CMR) of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grant no. ZZ9603, 01ZZ0103, 01ZZ0701) and the Ministry of Cultural Affairs, as well as the Social Ministry of the Federal State of Mecklenburg-West Pomerania (http://www.community-medicine.de). This work is also part of the research project Greifswald Approach to Individualized Medicine (GANI_MED). The GANI_MED consortium is funded by the Federal Ministry of Education and Research and the Ministry of Cultural Affairs of the Federal State of Mecklenburg – West Pomerania (03IS2061A). B. H. was supported by unlimited educational grant by GABA, Switzerland.
There are no conflicts of interest associated with this work.
- Issue published online: 6 SEP 2012
- Article first published online: 9 AUG 2012
- Accepted manuscript online: 10 JUL 2012 06:51AM EST
- Manuscript Accepted: 28 JUN 2012
- Federal Ministry of Education and Research. Grant Numbers: ZZ9603, 01ZZ0103, 01ZZ0701
- Ministry of Cultural Affairs
- Social Ministry of the Federal State of Mecklenburg-West Pomerania
- clinical attachment loss;
- serum IGFBP-3;
- serum IGF-I;
- tooth loss
To evaluate the association of Insulin-like Growth Factor (IGF) I-related variables with periodontitis in the population-based Study of Health in Pomerania (SHIP).
Material and Methods
From the cross-sectional SHIP, 2293 subjects with clinical attachment loss (CAL) data and 2398 subjects with tooth count data aged 20–59 years were analysed. Serum IGF-I and IGF-binding protein (BP)-3 levels were determined by chemiluminescence immunoassays. Linear and logistic regressions with fractional polynomials were used to study associations between IGF-related variables and mean CAL or high tooth loss. For non-linear relations between IGFBP-3 and mean CAL, graphical presentations of fractional polynomials were used to deduce knots for linear splines.
In fully adjusted models, for serum IGFBP-3 values ≤1200 ng/ml, mean CAL increased significantly for decreasing serum IGFBP-3 levels [B = −0.027 (95% CI, −0.049; −0.005), p = 0.02]. The odds for high tooth loss decreased significantly for high serum IGFBP-3 values [OR = 0.97 (0.95; 0.99), p = 0.02]. Serum IGF-I levels and the IGF-I/IGFBP-3 ratio were not related to mean CAL or tooth loss after full adjustment.
Low serum IGFBP-3 levels might be associated with higher levels of periodontal disease. Neither serum IGF-I nor IGF-I/IGFBP-3 ratios were associated with periodontitis.