Get access

Association between the insulin-like growth factor axis in serum and periodontitis in the Study of Health in Pomerania: an exploratory study

Authors

  • Ali N. Harb,

    1. Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, Dental school, University Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Search for more papers by this author
  • Birte Holtfreter,

    1. Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, Dental school, University Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Search for more papers by this author
  • Nele Friedrich,

    1. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Search for more papers by this author
  • Henri Wallaschofski,

    1. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Search for more papers by this author
  • Matthias Nauck,

    1. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Search for more papers by this author
  • Martin Albers,

    1. Department of SHIP/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Search for more papers by this author
  • Peter Meisel,

    1. Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, Dental school, University Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Search for more papers by this author
  • Reiner Biffar,

    1. Department of Prosthodontics, Gerodontology, and Biomaterials, Dental school, University Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Search for more papers by this author
  • Thomas Kocher

    Corresponding author
    • Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, Dental school, University Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Search for more papers by this author

  • Conflict of interests and source of funding statement
  • SHIP is part of the Community Medicine Research net (CMR) of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grant no. ZZ9603, 01ZZ0103, 01ZZ0701) and the Ministry of Cultural Affairs, as well as the Social Ministry of the Federal State of Mecklenburg-West Pomerania (http://www.community-medicine.de). This work is also part of the research project Greifswald Approach to Individualized Medicine (GANI_MED). The GANI_MED consortium is funded by the Federal Ministry of Education and Research and the Ministry of Cultural Affairs of the Federal State of Mecklenburg – West Pomerania (03IS2061A). B. H. was supported by unlimited educational grant by GABA, Switzerland.
  • There are no conflicts of interest associated with this work.

Address:

Thomas Kocher

Department of Restorative Dentistry, Periodontology and Endodontology

Unit of Periodontology

Ernst-Moritz-Arndt-University Greifswald

University Medicine

Rotgerberstraße 8, 17475 Greifswald

Germany

E-mail: kocher@uni-greifswald.de

Abstract

Aim

To evaluate the association of Insulin-like Growth Factor (IGF) I-related variables with periodontitis in the population-based Study of Health in Pomerania (SHIP).

Material and Methods

From the cross-sectional SHIP, 2293 subjects with clinical attachment loss (CAL) data and 2398 subjects with tooth count data aged 20–59 years were analysed. Serum IGF-I and IGF-binding protein (BP)-3 levels were determined by chemiluminescence immunoassays. Linear and logistic regressions with fractional polynomials were used to study associations between IGF-related variables and mean CAL or high tooth loss. For non-linear relations between IGFBP-3 and mean CAL, graphical presentations of fractional polynomials were used to deduce knots for linear splines.

Results

In fully adjusted models, for serum IGFBP-3 values ≤1200 ng/ml, mean CAL increased significantly for decreasing serum IGFBP-3 levels [B = −0.027 (95% CI, −0.049; −0.005), p = 0.02]. The odds for high tooth loss decreased significantly for high serum IGFBP-3 values [OR = 0.97 (0.95; 0.99), p = 0.02]. Serum IGF-I levels and the IGF-I/IGFBP-3 ratio were not related to mean CAL or tooth loss after full adjustment.

Conclusions

Low serum IGFBP-3 levels might be associated with higher levels of periodontal disease. Neither serum IGF-I nor IGF-I/IGFBP-3 ratios were associated with periodontitis.

Ancillary