Tooth loss and risk of hip fracture: a prospective study of male Japanese dentists
Version of Record online: 30 JUN 2012
© 2012 John Wiley & Sons A/S
Community Dentistry and Oral Epidemiology
Volume 41, Issue 1, pages 48–54, February 2013
How to Cite
Wakai K, Naito M, Naito T, Kojima M, Nakagaki H, Umemura O, Yokota M, Hanada N, Kawamura T. Tooth loss and risk of hip fracture: a prospective study of male Japanese dentists. Community Dent Oral Epidemiol 2012. © 2012 John Wiley & Sons A/S
- Issue online: 25 JAN 2013
- Version of Record online: 30 JUN 2012
- Manuscript Accepted: 24 MAY 2012
- Manuscript Received: 9 MAR 2011
- Ministry of Health, Labour and Welfare of Japan
- Grants for Scientific Research. Grant Numbers: 14770166, 16390189, 20590642, 23590788
- cohort studies;
- hip fracture;
- tooth loss
To determine whether the number of teeth lost can predict the risk of subsequent hip fracture.
We followed up 9992 male Japanese dentists aged 50 years or more (mean age ± standard deviation [SD], 61.1 ± 9.6 years) for incidence of hip fracture. From 2001 through 2006, they completed a baseline questionnaire on lifestyle and health factors including the number of teeth lost (excluding third molars). Incidence rate ratios (IRRs) were estimated by fitting proportional hazard models.
During the mean follow-up period of 6.0 years, 20 new cases of hip fracture occurred. Participants who had lost 15 or more teeth at baseline were at a significantly increased risk of hip fracture: the multivariate-adjusted IRRs were 4.1 (95% confidence interval [CI], 1.2–14.2) for loss of 15–27 teeth and 4.5 (1.1–18.0) for edentulousness relative to loss of 0–14 teeth (trend P, 0.028). Overall, the risk of hip fracture was weakly associated with the number of teeth lost: the IRR per tooth was 1.06 (95% CI, 1.01–1.12).
Tooth loss was slightly associated with a higher risk of subsequent hip fracture. The number of teeth lost might be informative in predicting this risk.