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Photosensitivity to piroxicam: absence of cross-reaction with tenoxicam
Article first published online: 11 APR 2006
DOI: 10.1111/j.1600-0536.1992.tb03281.x
1600-0536/asset/cover.gif?v=1&s=dbc3f5f5384e7cd094633414792bf89afed47532 "Contact Dermatitis")
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How to Cite
Gonçalo, M., Figueiredo, A., Tavares, P., Fontes Ribeiro, C. A., Teixeira, F. and Polares Baptista, A. (1992), Photosensitivity to piroxicam: absence of cross-reaction with tenoxicam. Contact Dermatitis, 27: 287–290. doi: 10.1111/j.1600-0536.1992.tb03281.x
Publication History
- Issue published online: 11 APR 2006
- Article first published online: 11 APR 2006
- Accepted for publication 7 April 1992
- Abstract
- References
- Cited By
Keywords:
- piroxicam;
- tenoxicam;
- thimerosal;
- thiosalicylic acid;
- NSAIDs;
- photosensitivity, medicaments. lack of corss-sensitivity;
- chemical basis;
- allergen replacement
We studied 2 groups of patients. One group or 10 patients had a photosensitive eruption to piroxicam. Another group of 24 patients had positive patch test reactions to thimerosal and thiosalicylie acid and had never taken piroxicam or tenoxicam. Patients were patch tested with thimerosal 0.1% pet., thiasalicylic acid 0.1% pet., salicylic acid 2.0% pet., piroxicam 1 and 5% pet. and tenoxicam 1 and 5% pet. photopatch tests were also performed with piroxicam and tenoxicam. All 10 patients with photosensitivity to piroxicam had positive patch tests to thiosalicylic and thiosalicylic acid and 9 of them had positive photopatch tests to ptroxicam. 20 out of 24 patients with positive patch tests to thiosalicylic acid also had positive photopatch tests to Piroxicam. All the patients tested with salicylic add were negative. Out of the 29 patients with positive photopatch tests to piroxicam, none reacted to tenoxicam. In countries with a high incidence of contact sensitivity to thimerosal/thiosalicylic acid, the use of piroxicam should be avoided and replaced by tenoxicam, a drug without reported photosensitivity