The sodium lauryl sulfate model: an overview

Authors

  • Cheol Heon Lee,

    1. Department of Dermatology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University Seoul, 150–071 Korea
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  • Howard I. Maibach

    Corresponding author
    1. Department of Dermatology, School of Medicine, University Of California, Box 0989, Surge 110, San Francisco, CA, 94143–0989, USA
    • Howard I Maibach, Department of Dermatology, School of Medicine, University of California, Box 0989, Surge 110, San Francisco, CA, 94143-0989, USA

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Abstract

Irritant contact dermatitis is a complex entity with several clinical forms (acute, cumulative, etc.) and multiple mechanisms. Sodium lauryl sulfate (SLS), the most widely utilized model for studying acute and cumulative irritation, has proved highly practical and informative for such studies. This article summarizes several decade of investigation, and provides details of dosing, application method (closed versus open), and biologic endpoints (visual grading, transpidermal water loss) that may be utilized in future studies.

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