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Keywords:

  • heparin, delayed hypersensitivity;
  • eczema;
  • drug reaction;
  • cutaneous side-effects;
  • intradermal tests;
  • subcutaneous tests;
  • patch testing technique

We report a case of delayed hypersensitivity to a low-molecular-weight heparin. The patient presented with eczema at the site of subcutaneous injections and allergy testes confirmed the clinical diagnosis. There were positive tests with 3 low-molecular-weight heparins and unfractionated subcutaneous calcium heparin but negative with intravenous sodium heparin. Although delayed hyper-sensitivity to low-molecular-weight heparins is rare, the possibility of cross-allergy to unfractionated heparin could be a therapeutic problem for some patients.