• fragrance mix;
  • constituents;
  • cosmetic allergy;
  • exposure concentrations;
  • relevance of patch test reactions

The aim of the present study was to assess exposure to constituents of the fragrance mix from cosmetic products used by fragrance-mix-positive eczema patients. 23 products, which had either given a positive patch and/or use test in a total of 11 fragrance-mix-positive patients, were analyzed. In all cases, the use of these cosmetics completely or partly explained present or past episodes of eczema. Between 1 to 6 constituents of the fragrance mix were found in 22 out of 21 products. The cosmetics of all the patients sensitive to hydroxycitronellal, eugenol, cinnamic alcohol and α- amylcinnamic aldehyde were found to contain the respective substances. Exposure concentrations were seen in cover a large range. The content of hydroxycitronellal was, on average, 5×higher in cosmetics from hydroxycitronellal-sensitive patients, compared to cosmetics from hydroxycitronellal-negative patients. It is concluded that exposure to constituents of the fragrance mix is common in fragrance-allergic patients with cosmetic eczema, and that the fragrance mix is a good relied inn of actual exposure.