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Air oxidation increases skin irritation from fragrance terpenes

Authors

  • Johanna Bråred Christensson,

    Corresponding author
    1. Department of Dermatology, Sahlgrenska University Hospital, 41345 Gothenburg
    2. Dermatochemistry and Skin Allergy, Department of Chemistry, University of Gothenburg, 41296 Gothenburg, Sweden
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  • Pia Forsström,

    1. Dermatochemistry and Skin Allergy, Department of Chemistry, University of Gothenburg, 41296 Gothenburg, Sweden
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  • Ann-Marie Wennberg,

    1. Department of Dermatology, Sahlgrenska University Hospital, 41345 Gothenburg
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  • Ann-Therese Karlberg,

    1. Dermatochemistry and Skin Allergy, Department of Chemistry, University of Gothenburg, 41296 Gothenburg, Sweden
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  • Mihály Matura

    1. Department of Dermatology, Sahlgrenska University Hospital, 41345 Gothenburg
    2. Dermatochemistry and Skin Allergy, Department of Chemistry, University of Gothenburg, 41296 Gothenburg, Sweden
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    • *

      Current address: Unit of Occupational and Environmental Dermatology, Department of Occupational and Environmental Health, Stockholm Centre for Public Health, Stockholm, Sweden.


Johanna Bråred Christensson
Department of Dermatology
Sahlgrenska University Hospital
413 45 Gothenburg
Sweden
Tel: +4631 3421000
Fax: +4631 821871
e-mail: johanna.brared-christensson@vgregion.se

Abstract

Background:  Linalool and limonene are common fragrance terpenes that autoxidize on air exposure. The pure compounds are not allergenic but their oxidation products can cause contact allergy. Little has been investigated regarding the irritancy of oxidized terpenes.

Aim:  The aim of this study was to investigate the irritating effect of pure and oxidized R-limonene and linalool in concentration series and to study the MNIC (Maximum Non Irritant Concentration) of autoxidized linalool and limonene.

Patients/methods:  Patch testing was performed in dermatitis patients and controls with sequentially diluted concentrations of oxidized and non-oxidized linalool, and oxidized and non-oxidized R-limonene. Readings were made with visual assessment and using laser Doppler imaging.

Results:  The non-oxidized terpenes were non-irritating in all tested concentrations. Both linalool and especially R-limonene were more irritating after oxidation compared with the pure compounds. No difference in response was seen between dermatitis patients and controls.

Conclusion:  Autoxidation of the fragrance terpenes linalool and R-limonene increases irritation. Oxidized linalool is less irritating than oxidized R-limonene. In this study, we found no advantages in using laser Doppler technique compared with visual assessment.

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