Lichenoid and granulomatous dermatitis associated with atypical mycobacterium infections

Authors


Cynthia M. Magro, MD, Department of Pathology, The Ohio State University, N305 Doan Hall, 410 West 10th Avenue, Columbus, OH 43221, USA
Tel: +1 614 293 5292
Fax: +1 614 293 7634
e-mail: magro-1@medctr.osu.edu

Abstract

Background:  Lichenoid and granulomatous dermatitis defines a distinctive pattern of cutaneous inflammation that may be part of the morphologic spectrum of idiopathic lichenoid reactions such as lichen planus and as well may be seen with lichenoid drug reactions, endogenous T-cell dyscrasias and as a feature of certain systemic diseases especially Crohn's disease and rheumatoid arthritis.

Results:  We encountered three cases of lichenoid and granulomatous dermatitis in which the basis was one of primary cutaneous Mycobacterium infection. In all three cases acid fast stains revealed pathogenic organisms and as well cultures were positive for Mycobacterium kansasii in one case and Mycobacterium marinum in another. Other features included a prominent perineural and periadnexal lymphocytic infiltrate.

Conclusions:  The differential diagnosis of lichenoid and granulomatous dermatitis should also encompass primary cutaneous Mycobacterium infection in addition to the other more characteristic entities associated wtih this distinctive reaction pattern. Infection with Mycobacterium induces a TH1 dominant response which would hence produce an infiltrate.

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