Get access

Eccrine angiomatous hamartoma with features resembling verrucous hemangioma

Authors

  • Anjela Galan,

    Corresponding author
    1. Departments of Dermatology
      Anjela Galan, MD, Department of Dermatology, Yale
      University School of Medicine, 15 York Str, LMP
      5031, New Haven, CT, USA
      Tel: +1 203 785 4094
      e-mail: anjela.galan@yale.edu
    Search for more papers by this author
  • Jennifer M. McNiff

    1. Departments of Dermatology
    2. Pathology Yale University School of Medicine, New Haven, CT, USA
    Search for more papers by this author

  • A.G. and J.M.M. declare no conflicts of interest

Anjela Galan, MD, Department of Dermatology, Yale
University School of Medicine, 15 York Str, LMP
5031, New Haven, CT, USA
Tel: +1 203 785 4094
e-mail: anjela.galan@yale.edu

Abstract

Eccrine angiomatous hamartoma (EAH) is a benign malformation characterized by a proliferation of eccrine glands and capillary vessels in the dermis. Hyperplasia of other dermal constituents, such as fat, nerve fibers, pilar structures and dermal mucin, has been reported. EAH typically presents as a painful lesion on the extremities of children or young adults and may be associated with local hyperhidrosis. We report a case of a 7-year-old boy with a keratotic lesion on the ankle, present since birth. Histologically, there was a nodular proliferation of eccrine glands intimately admixed with numerous small vessels in the dermis. In addition, there was marked epidermal hyperplasia associated with increased numbers of dilated, thin-walled vessels in the superficial and mid-dermis. The vessels were negative for glucose transporter-1 protein (GLUT-1), supporting the impression of hamartoma over that of hemangioma. EAH has been described in association with spindle cell hemangioma and arteriovenous malformation; overlying verrucous epidermal features have been noted in rare cases. However, changes resembling verrucous hemangioma associated with EAH, as seen in this case, have not been emphasized in the literature. The findings are unusual and expand the histological spectrum of this hamartoma.

Get access to the full text of this article

Ancillary