Large CD30-positive cells in benign, atypical lymphoid infiltrates of the skin
Article first published online: 9 JUL 2008
© Blackwell Munksgaard 2008
Journal of Cutaneous Pathology
Volume 35, Issue 12, pages 1100–1107, December 2008
How to Cite
Werner, B., Massone, C., Kerl, H. and Cerroni, L. (2008), Large CD30-positive cells in benign, atypical lymphoid infiltrates of the skin. Journal of Cutaneous Pathology, 35: 1100–1107. doi: 10.1111/j.1600-0560.2007.00979.x
- Issue published online: 30 OCT 2008
- Article first published online: 9 JUL 2008
Background: Cutaneous infectious and inflammatory diseases may contain a significant number of CD30-positive cells, thus mimicking lymphomatoid papulosis (LyP) or anaplastic large cell lymphoma.
Methods: We reviewed our cases of non-neoplastic skin conditions with large, CD30-positive cells and searched the literature for similar cases.
Results: A total of 28 cases were included in the study: Milker’s nodule (n = 8), Herpes simplex virus infection (n = 7), lymphomatoid drug reaction (n = 3), molluscum contagiosum (n = 3), nodular scabies (n = 2), leishmaniasis (n = 1), syphilis (n = 1), pernio (n = 1), ruptured infundibular cyst (n = 1) and pseudolymphoma in a scar (n = 1). CD30-positive cells were often arranged in clusters and revealed both Golgi and membrane positivity, similar to what was observed in LyP and CD30+ anaplastic large T-cell lymphoma.
Conclusions: Analysis of our data and of those published in the literature shows that viruses and drugs are the most common cause for occurrence of large CD30-positive cells in cutaneous pseudolymphomatous infiltrates. Arrangement of these large, CD30-positive cells in small clusters is not unique to cutaneous CD30-positive lymphomas, and in many cases a precise diagnosis can be made only upon accurate clinicopathological correlation or using ancillary methods such as polymerase chain reaction analysis for viral DNA.